Evidence map›Paper›PMID 38650295›Full record

ReviewBioresources and bioprocessing2021

Laccases as green and versatile biocatalysts: from lab to enzyme market-an overview.

Tatiane Brugnari, Dayane Moreira Braga, Camila Souza Almeida Dos Santos, Bruno Henrique Czelusniak Torres, Tatiani Andressa Modkovski, Charles Windson Isidoro Haminiuk, Giselle Maria Maciel

Open access · diamondAbstract readReview
In one paragraph

Review in Bioresources and bioprocessing, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
14.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 105 citations in OpenAlex.

  1. Review
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  7. Production ofMolecules (Basel, Switzerland) · 2025
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  15. Review
  16. Copper increases laccase gene transcription and extracellular laccase activity in Pleurotus eryngii KS004.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2024
    Article
  17. Article
  18. Article
  19. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Tatiane BrugnariBiotechnology Laboratory, Department of Chemistry and Biology, Graduate Program in Environmental Science and Technology, Federal University of Technology, Paraná, Curitiba, Brazil. tatiane.bru@gmail.com.ORCID http://orcid.org/0000-0003-2864-7976
Dayane Moreira BragaBiotechnology Laboratory, Department of Chemistry and Biology, Graduate Program in Environmental Science and Technology, Federal University of Technology, Paraná, Curitiba, Brazil.
Camila Souza Almeida Dos SantosBiotechnology Laboratory, Department of Chemistry and Biology, Graduate Program in Environmental Science and Technology, Federal University of Technology, Paraná, Curitiba, Brazil.
Bruno Henrique Czelusniak TorresBiotechnology Laboratory, Department of Chemistry and Biology, Graduate Program in Environmental Science and Technology, Federal University of Technology, Paraná, Curitiba, Brazil.
Tatiani Andressa ModkovskiBiotechnology Laboratory, Department of Chemistry and Biology, Graduate Program in Environmental Science and Technology, Federal University of Technology, Paraná, Curitiba, Brazil.
Charles Windson Isidoro HaminiukBiotechnology Laboratory, Department of Chemistry and Biology, Graduate Program in Environmental Science and Technology, Federal University of Technology, Paraná, Curitiba, Brazil.
Giselle Maria MacielBiotechnology Laboratory, Department of Chemistry and Biology, Graduate Program in Environmental Science and Technology, Federal University of Technology, Paraná, Curitiba, Brazil.
Universidade Tecnológica Federal do Paraná · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Laccases are multi-copper oxidase enzymes that catalyze the oxidation of different compounds (phenolics and non-phenolics). The scientific literature on laccases is quite extensive, including many basic and applied research about the structure, functions, mechanism of action and a variety of biotechnological applications of these versatile enzymes. Laccases can be used in various industries/sectors, from the environmental field to the cosmetics industry, including food processing and the textile industry (dyes biodegradation and synthesis). Known as eco-friendly or green enzymes, the application of laccases in biocatalytic processes represents a promising sustainable alternative to conventional methods. Due to the advantages granted by enzyme immobilization, publications on immobilized laccases increased substantially in recent years. Many patents related to the use of laccases are available, however, the real industrial or environmental use of laccases is still challenged by cost-benefit, especially concerning the feasibility of producing this enzyme on a large scale. Although this is a compelling point and the enzyme market is heated, articles on the production and application of laccases usually neglect the economic assessment of the processes. In this review, we present a description of laccases structure and mechanisms of action including the different sources (fungi, bacteria, and plants) for laccases production and tools for laccases evolution and prediction of potential substrates. In addition, we both compare approaches for scaling-up processes with an emphasis on cost reduction and productivity and critically review several immobilization methods for laccases. Following the critical view on production and immobilization, we provide a set of applications for free and immobilized laccases based on articles published within the last five years and patents which may guide future strategies for laccase use and commercialization.

Indexed as

BiocatalystsImmobilizationLigninolytic enzymesMulti-copper oxidasesPatents

Identifiers

PMID38650295
PMCPMC10991308
OpenAlexW4200596421

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.