Evidence map›Paper›PMID 38650200›Full record

ArticleBioresources and bioprocessing2021

Biosynthesis of lactones from diols mediated by an artificial flavin.

Xiaowang Zhang, Zhuotao Tan, Chaojian Li, Siyu Qi, Mengjiao Xu, Ming Li, Wenlong Xiong, Wei Zhuang, Dong Liu, Chenjie Zhu and 1 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioresources and bioprocessing, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.1field-weighted citation impact, top 56% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Xiaowang ZhangCollege of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing, China.
Zhuotao TanCollege of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing, China.
Chaojian LiTechnology Center, China Tobacco Jiangsu Industry Co., Ltd., Nanjing, 210019, Jiangsu, China.
Siyu QiSchool of Life Sciences, Zhengzhou University, Zhengzhou, China.
Mengjiao XuCollege of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing, China.
Ming LiCollege of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing, China.
Wenlong XiongSchool of Life Sciences, Zhengzhou University, Zhengzhou, China.
Wei ZhuangCollege of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing, China.
Dong LiuCollege of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing, China. liudong@njtech.edu.cn.
Chenjie ZhuCollege of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing, China. zhucj@njtech.edu.cn.ORCID http://orcid.org/0000-0001-7917-3649
Hanjie YingCollege of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing, China.
Nanjing Tech University · CNZhengzhou University · CNChina Tobacco · CN

Funding

National Key Research and Development Program of China 2019YFD1101202National Natural Science Foundation of China 21776132
6 · The paper itself

Abstract

backgroundLactones are important compounds in the field of medicine, material and chemical industry. One of the promising accesses to these flexible scaffolds is NAD(P)

resultsIn this study, a novel system combining horse liver alcohol dehydrogenase (HLADH) with the synthetic bridged flavin cofactor was established for biosynthesis of lactones. The reaction conditions of this system were optimized and a variety of lactones including chiral lactones were efficiently obtained from various diols. Compared to the previously reported NAD(P)

conclusionsThis study provides an efficient method to synthesis of lactones from diols under mild conditions. We believe this system will be a promising alternative to promote the synthesis of other valuable compounds.

Indexed as

BiosynthesisCofactor regenerationDiolsFlavinLactones

Identifiers

PMID38650200
PMCPMC10991483
OpenAlexW3194569562

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.