ArticleBreast cancer research : BCR2024
Clustering of HR + /HER2- breast cancer in an Asian cohort is driven by immune phenotypes.
Article in Breast cancer research : BCR, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
6 citing papers in PubMed, 5 citations in OpenAlex.
- Motherhood's immune legacy reshapes the breast for lasting cancer defence.Immuno-oncology technology · 2026Article
- The clinicopathological and imaging parameters contributing to the similarity network fusion subtypes and prognosis of hormone receptor-positive HER2-negative breast cancer: an exploratory study.Quantitative imaging in medicine and surgery · 2026Article
- Immunotherapy in Asia: current insights and prospects in Southeast Asia and Malaysia.Frontiers in oncology · 2026Review
- Article
- Characterization of intra-tumoral microbiota from transcriptomic sequencing of Asian breast cancer.Scientific reports · 2025Article
- Causal relationships between immune cell traits and HER2 subtypes in breast cancer: a Mendelian randomization study.Discover oncology · 2025Article
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Authors and funding
17 authors at 6 institutions in 2 countries.
Funding
Abstract
Breast cancer exhibits significant heterogeneity, manifesting in various subtypes that are critical in guiding treatment decisions. This study aimed to investigate the existence of distinct subtypes of breast cancer within the Asian population, by analysing the transcriptomic profiles of 934 breast cancer patients from a Malaysian cohort. Our findings reveal that the HR + /HER2- breast cancer samples display a distinct clustering pattern based on immune phenotypes, rather than conforming to the conventional luminal A-luminal B paradigm previously reported in breast cancers from women of European descent. This suggests that the activation of the immune system may play a more important role in Asian HR + /HER2- breast cancer than has been previously recognized. Analysis of somatic mutations by whole exome sequencing showed that counter-intuitively, the cluster of HR + /HER2- samples exhibiting higher immune scores was associated with lower tumour mutational burden, lower homologous recombination deficiency scores, and fewer copy number aberrations, implicating the involvement of non-canonical tumour immune pathways. Further investigations are warranted to determine the underlying mechanisms of these pathways, with the potential to develop innovative immunotherapeutic approaches tailored to this specific patient population.
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Registered trials
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