ArticleBMC geriatrics2024
Assessing the relationship between multimorbidity, NCD configurations, frailty phenotypes, and mortality risk in older adults.
Article in BMC geriatrics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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12 citing papers in PubMed.
- Effects of a blended face-to-face and eHealth lifestyle intervention on physical activity, diet, and health outcomes in Hong Kong community-dwelling older adults: a randomized controlled trial.BMC public health · 2025Trial
- Unsupervised Clinical Phenotyping Identifies Distinct Risk Profiles in Incisional Hernia Repair.Medicina (Kaunas, Lithuania) · 2026Article
- Physical frailty, depression and multimorbidity among older adults in Lima, Peru: a cross-sectional study.BMC geriatrics · 2026Article
- Frailty progression: The role of multimorbidity configurations in frailty transitions and predicting mortality risk among older adults.BMC medicine · 2026Article
- Socioeconomic disparities and nutritional aging: how food insecurity and financial hardship accelerate health decline in older adults.Frontiers in nutrition · 2026Review
- Frailty as a predictor of mortality in lung cancer survivors: evidence from a nationally representative cohort NHIS 1997-2018.Scientific reports · 2025Article
- BUN-to-ALB ratio as an effective predictor of 30 day mortality in ADHF patients in eastern China.ESC heart failure · 2025Article
- Multimorbidity patterns in older adults from Northern Netherlands: comparing factor analysis and latent class analysis solutions.BMC geriatrics · 2025Article
- The impact of inflammatory burden index on the prognosis in acute decompensated heart failure: evidence from a cohort study in Jiangxi, China.Frontiers in cardiovascular medicine · 2025Article
- Data-driven frailty and reserve phenotypes in older outpatients: a cluster analysis of complementary geriatric assessment.Frontiers in aging · 2025Article
- The systemic inflammation response index as a significant predictor of short-term adverse outcomes in acute decompensated heart failure patients: a cohort study from Southern China.Frontiers in endocrinology · 2024Article
- Depression and Plasma pTauGerontology & geriatric medicineArticle
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6 authors.
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Abstract
backgroundOlder adults are increasingly susceptible to prolonged illness, multiple chronic diseases, and disabilities, which can lead to the coexistence of multimorbidity and frailty. Multimorbidity may result in various noncommunicable disease (NCD) patterns or configurations that could be associated with frailty and death. Mortality risk may vary depending on the presence of specific chronic diseases configurations or frailty.
methodsThe aim was to examine the impact of NCD configurations on mortality risk among older adults with distinct frailty phenotypes. The population was analyzed from the Costa Rican Longevity and Healthy Aging Study Cohort (CRELES). A total of 2,662 adults aged 60 or older were included and followed for 5 years. Exploratory factor analysis and various clustering techniques were utilized to identify NCD configurations. The frequency of NCD accumulation was also assessed for a multimorbidity definition. Frailty phenotypes were set according to Fried et al. criteria. Kaplan‒Meier survival analyses, mortality rates, and Cox proportional hazards models were estimated.
resultsFour different types of patterns were identified: 'Neuro-psychiatric', 'Metabolic', 'Cardiovascular', and 'Mixt' configurations. These configurations showed a higher mortality risk than the mere accumulation of NCDs [Cardiovascular HR:1.65 (1.07-2.57); 'Mixt' HR:1.49 (1.00-2.22); ≥3 NCDs HR:1.31 (1.09-1.58)]. Frailty exhibited a high and constant mortality risk, irrespective of the presence of any NCD configuration or multimorbidity definition. However, HRs decreased and lost statistical significance when phenotypes were considered in the Cox models [frailty + 'Cardiovascular' HR:1.56 (1.00-2.42); frailty + 'Mixt':1.42 (0.95-2.11); and frailty + ≥ 3 NCDs HR:1.23 (1.02-1.49)].
conclusionsFrailty accompanying multimorbidity emerges as a more crucial indicator of mortality risk than multimorbidity alone. Therefore, studying NCD configurations is worthwhile as they may offer improved risk profiles for mortality as alternatives to straightforward counts.
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