ArticleNature communications2024
Clinical associations with a polygenic predisposition to benign lower white blood cell counts.
Open access · goldAbstract read
In one paragraph
Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
3.2field-weighted citation impact, top 8% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed, 7 citations in OpenAlex.
- Clinical use of polygenic risk scores: current status, barriers and future directions.Nature reviews. Genetics · 2026Review
- Genetic nurture: estimating the direct genetic effects of pediatric anthropometric traits.Human molecular genetics · 2025Article
Corrections and comments
- Update of
Authors and funding
28 authors at 11 institutions in 1 country.
Jonathan D MosleyDepartment of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA. jonathan.d.mosley@vumc.org.ORCID http://orcid.org/0000-0001-6421-2887
John P ShelleyDepartment of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA.
Alyson L DicksonDepartment of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.ORCID http://orcid.org/0000-0003-3404-3802
Jacy ZanussiDepartment of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Laura L DanielDepartment of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.ORCID http://orcid.org/0000-0003-3143-5915
Neil S ZhengDepartment of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Lisa BastaracheDepartment of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA.
Wei-Qi WeiDepartment of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA.ORCID http://orcid.org/0000-0003-4985-056X
Mingjian ShiDepartment of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA.ORCID http://orcid.org/0000-0003-1569-9822
Gail P JarvikDepartment of Genome Sciences, University of Washington Medical Center, Seattle, WA, USA.
Elisabeth A RosenthalDepartment of Medicine (Medical Genetics), University of Washington Medical Center, Seattle, WA, USA.ORCID http://orcid.org/0000-0001-6042-4487
Atlas KhanDivision of Nephrology, Dept of Medicine, Vagelos College of Physicians & Surgeons, Columbia University, New York, NY, USA.ORCID http://orcid.org/0000-0002-6651-2725
Alborz SherafatiDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, USA.
Iftikhar J KulloDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, USA.ORCID http://orcid.org/0000-0002-6524-3471
Theresa L WalunasDepartment of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.ORCID http://orcid.org/0000-0002-7653-3650
Joseph GlessnerDepartment of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0001-5131-2811
Hakon HakonarsonDepartment of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0003-2814-7461
Nancy J CoxDepartment of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Dan M RodenDepartment of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.ORCID http://orcid.org/0000-0002-6302-0389
Stephan G FrangakisDepartment of Anesthesiology, University of Michigan Medical School, Ann Arbor, MI, USA.
Brett VanderwerffDepartment of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.
C Michael SteinDepartment of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Sara L Van DriestDepartment of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Scott C BorinsteinDepartment of Pediatrics, Vanderbilt University Medical Center, Nashville, TN, USA.ORCID http://orcid.org/0000-0002-1721-1520
Xiao-Ou ShuDepartment of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Matthew ZawistowskiDepartment of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0002-3005-083X
Cecilia P ChungDepartment of Medicine, University of Miami, Miami, FL, USA.
Vivian K KawaiDepartment of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Vanderbilt University Medical Center · USUniversity of Michigan · USMayo Clinic in Arizona · USUniversity of Washington Medical Center · USChildren's Hospital of Philadelphia · USColumbia University · USNorthwestern University · USUniversity of Miami · USUniversity of Pennsylvania · USVanderbilt University · USYale University · US
Funding
Vanderbilt Institute for Clinical and Translational Research (VICTR) -Identifying correlates of functional immunity in SARS-CoV-2 convalescent plasmaUL1TR002243 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Paul A. Harris, Wesley H Self · 2017 to 2026
$130.7MVANDERBILT UNIVERSITY CTSA FOR PEDIATRIC RESEARCHUL1RR024975 · NCRR · VANDERBILT UNIVERSITY · PI BERNARD, GORDON RAPHAEL · 2007 to 2011
$45.7MThe Vanderbilt Institute for Clinical and Translational Research (VICTR)UL1TR000445 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BERNARD, GORDON RAPHAEL · 2012 to 2016
$41.4MMEDICAL SCIENTIST TRAINING PROGRAMT32GM007347 · NIGMS · VANDERBILT UNIVERSITY · PI WILLIAMS, CHRISTOPHER S. · 1985 to 2023
$26.3MJH/CIDR Genotyping for Genome-Wide Association StudiesU01HG004438 · NHGRI · JOHNS HOPKINS UNIVERSITY · PI VALLE, DAVID · 2007 to 2011
$24.2MA Center for GEI Association StudiesU01HG004424 · NHGRI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI GABRIEL, STACEY · 2007 to 2010
$21.4MPharmacogenomics of Arrhythmia TherapyU19HL065962 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI RODEN, DAN M · 2010 to 2014
$17.4MGenomic Basis of Susceptibility to COVID-19 Infection and its ComplicationsU01HG006379 · NHGRI · MAYO CLINIC ROCHESTER · PI Richard R. Sharp · 2011 to 2026
$16.5MUnderstanding and preventing HLA-associated drug reactionsP50GM115305 · NIGMS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI DENNY, JOSHUA C. · 2015 to 2019
$13.0MThe Genetic Epemiology of Multiple SclerosisR01NS032830 · NINDS · VANDERBILT UNIVERSITY · PI HAINES, JONATHAN L · 1995 to 2010
$8.9MEpidemiologic Architecture for Genes Linked to Environment (EAGLE)U01HG004798 · NHGRI · VANDERBILT UNIVERSITY · PI CRAWFORD, DANA C · 2008 to 2013
$8.8MVanderbilt Genome-Electronic Records (VGER) ProjectU01HG011181 · NHGRI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI DAN M RODEN, Digna R Velez Edwards · 2020 to 2026
$7.0MNCATS NIH HHS UL1 TR000445NCATS NIH HHS UL1 TR002243NCRR NIH HHS S10 RR025141NCRR NIH HHS UL1 RR024975NHGRI NIH HHS U01 HG004424NHGRI NIH HHS U01 HG004438NHGRI NIH HHS U01 HG004798NHGRI NIH HHS U01 HG006375NHGRI NIH HHS U01 HG006378NHGRI NIH HHS U01 HG006379NHGRI NIH HHS U01 HG006380NHGRI NIH HHS U01 HG006382NHGRI NIH HHS U01 HG006385NHGRI NIH HHS U01 HG006388NHGRI NIH HHS U01 HG006389NHGRI NIH HHS U01 HG006828NHGRI NIH HHS U01 HG006830NHGRI NIH HHS U01 HG011181NHLBI NIH HHS U19 HL065962NIAMS NIH HHS K08 AR082454NICHD NIH HHS R01 HD074711NIGMS NIH HHS P50 GM115305NIGMS NIH HHS R01 GM126535NIGMS NIH HHS R01 GM130791NIGMS NIH HHS R35 GM131770NIGMS NIH HHS RC2 GM092618NIGMS NIH HHS T32 GM007347NIGMS NIH HHS T32 GM145449NIGMS NIH HHS T32 GM152284NINDS NIH HHS R01 NS032830
Abstract
Polygenic variation unrelated to disease contributes to interindividual variation in baseline white blood cell (WBC) counts, but its clinical significance is uncharacterized. We investigated the clinical consequences of a genetic predisposition toward lower WBC counts among 89,559 biobank participants from tertiary care centers using a polygenic score for WBC count (PGS
Indexed as
Genetic Predisposition to DiseaseLeukopeniaMultifactorial InheritancePolymorphism, Single NucleotideAdultAgedFemaleHumansImmunosuppressive AgentsLeukocyte CountMaleMiddle AgedImmunosuppressive Agents
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.