Evidence map›Paper›PMID 38649650›Full record

ArticleJournal of cancer survivorship : research and practice2025

Cardiovascular screening outcomes in the Dutch survivorship care program for Hodgkin lymphoma survivors.

Eline M J Lammers, Annelies Nijdam, Josée M Zijlstra, Cécile P M Janus, Roel J de Weijer, Yolande Appelman, Olivier C Manintveld, Arco J Teske, Flora E van Leeuwen, Berthe M P Aleman

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Article in Journal of cancer survivorship : research and practice, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

Eline M J LammersDepartment of Epidemiology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Annelies NijdamDepartment of Epidemiology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Josée M ZijlstraDepartment of Hematology, Amsterdam UMC Location Vrije Universiteit, Cancer Centre Amsterdam, Amsterdam, The Netherlands.
Cécile P M JanusDepartment of Radiation Oncology, Erasmus Medical Centre, Rotterdam, The Netherlands.
Roel J de WeijerDepartment of Hematology, University Medical Centre Utrecht, Utrecht, The Netherlands.
Yolande AppelmanDepartment of Cardiology, Amsterdam UMC, Location Vrije Universiteit, Amsterdam Cardiovascular Sciences, Amsterdam, The Netherlands.
Olivier C ManintveldDepartment of Cardiology, Erasmus Medical Centre, Rotterdam, The Netherlands.
Arco J TeskeDepartment of Cardiology, University Medical Centre Utrecht, Utrecht, The Netherlands.
Flora E van LeeuwenDepartment of Epidemiology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Berthe M P AlemanDepartment of Radiation Oncology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands. b.aleman@nki.nl.
Erasmus University Rotterdam · NLOncode Institute · NLThe Netherlands Cancer Institute · NLUniversity Medical Center Utrecht · NLVrije Universiteit Amsterdam · NL

Funding

KWF Kankerbestrijding NKI 2011-5270ZonMw 10330022010009
6 · The paper itself

Abstract

purposeHodgkin lymphoma (HL) survivors are at increased risk of cardiovascular disease (CVD) due to former lymphoma treatment. In 2013, cardiovascular screening for 5-year HL survivors according to national guidelines was implemented in Dutch survivorship clinics. We aim to assess the following: (1) adherence to screening guidelines and (2) the yield of (risk factors for) CVD in the screening program.

methodsThe study population consisted of 5-year HL survivors who received survivorship care at three University Medical Centers from 2013 to 2016 through 2021. Patient characteristics, cardiovascular screening procedures, and outcomes were collected from the medical records.

resultsIn 186 survivors eligible for cardiovascular screening (mean age 47.8 years, 60.8% female), the following diagnostics were performed: complete blood tests (81.0%, median frequency: yearly instead of advised 5-yearly evaluation), electrocardiogram (93.0%), echocardiography (94.6%). Fifty-five percent of survivors had at least one modifiable cardiovascular risk factor (i.e., current smoking, overweight, new/insufficiently controlled hypertension, dyslipidemia, or diabetes). Screening detected ≥ 1 CVD in 31.1% of survivors. Among survivors with available echocardiography report (n = 106), screening detected new aortic and/or mitral valve dysfunction(s) in 51.0% (with grades 3-4 in 4.9%) and impaired left ventricular ejection fraction in 10.3%.

conclusionsAdherence to the screening guidelines in the Dutch HL survivorship care program was reasonable to good and a substantial number of actionable (risk factors for) CVD were diagnosed. IMPLICATIONS FOR CANCER SURVIVORS: Our findings inform HL survivors at high risk of late cardiotoxicity about cardiovascular screening findings and demonstrate appropriate therapeutic actions after diagnosis of (risk factors for) CVD.

Indexed as

Cancer SurvivorsCardiovascular DiseasesHodgkin DiseaseMass ScreeningAdultAgedFemaleHumansMaleMiddle AgedNetherlandsRisk FactorsSurvivorshipCardiovascular diseaseCardiovascular risk factorsHodgkin lymphomaScreeningSurvivorship care

Identifiers

PMID38649650
OpenAlexW4395047606

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.