Evidence map›Paper›PMID 38649645›Full record

ArticleCellular and molecular neurobiology2024

Inhibition of UHRF1 Improves Motor Function in Mice with Spinal Cord Injury.

Shuai Cheng, Hui Guo, Mingyu Bai, Yang Cui, He Tian, Xifan Mei

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cellular and molecular neurobiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Shuai ChengSchool of Basic Medicine, Jinzhou Medical University, Jinzhou, China.ORCID http://orcid.org/0009-0000-6586-6022
Hui GuoSchool of Basic Medicine, Jinzhou Medical University, Jinzhou, China.ORCID http://orcid.org/0009-0009-4460-4467
Mingyu BaiLiaoning Provincial Collaborative Innovation Center for Medical Testing and Drug Research, Jinzhou Medical University, Jinzhou, Liaoning, China.ORCID http://orcid.org/0009-0003-4581-2299
Yang CuiLiaoning Provincial Collaborative Innovation Center for Medical Testing and Drug Research, Jinzhou Medical University, Jinzhou, Liaoning, China.ORCID http://orcid.org/0009-0001-9776-7341
He TianSchool of Basic Medicine, Jinzhou Medical University, Jinzhou, China. tianhe@jzmu.edu.cn.ORCID http://orcid.org/0000-0001-8105-9773
Xifan MeiSchool of Basic Medicine, Jinzhou Medical University, Jinzhou, China. meixifan@jzmu.edu.cn.ORCID http://orcid.org/0000-0002-4452-8005
Jinzhou Medical University · CN

Funding

National Natural Science Foundation of China 82272256
6 · The paper itself

Abstract

Spinal-cord injury (SCI) is a severe condition that can lead to limb paralysis and motor dysfunction, and its pathogenesis is not fully understood. The objective of this study was to characterize the differential gene expression and molecular mechanisms in the spinal cord of mice three days after spinal cord injury. By analyzing RNA sequencing data, we identified differentially expressed genes and discovered that the immune system and various metabolic processes play crucial roles in SCI. Additionally, we identified UHRF1 as a key gene that plays a significant role in SCI and found that SCI can be improved by suppressing UHRF1. These findings provide important insights into the molecular mechanisms of SCI and identify potential therapeutic targets that could greatly contribute to the development of new treatment strategies for SCI.

Indexed as

CCAAT-Enhancer-Binding ProteinsSpinal Cord InjuriesUbiquitin-Protein LigasesAnimalsFemaleGene Expression RegulationMiceMice, Inbred C57BLMotor ActivityRecovery of FunctionSpinal CordCCAAT-Enhancer-Binding ProteinsUbiquitin-Protein LigasesUhrf1 protein, mouseImmunityMicroenvironmentMolecular regulationSpinal-cord injuryUHRF1

Identifiers

PMID38649645
PMCPMC11035417
OpenAlexW4394996741

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.