Evidence map›Paper›PMID 38649556›Full record

ReviewActa neurologica Belgica2024

Recommendations for the management of myasthenia gravis in Belgium.

Jan L De Bleecker, Gauthier Remiche, Alicia Alonso-Jiménez, Vinciane Van Parys, Véronique Bissay, Stéphanie Delstanche, Kristl G Claeys

Open access · hybridAbstract readReview
In one paragraph

Review in Acta neurologica Belgica, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
8.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.

  1. Pooled it
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  11. Observational
  12. Article
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  15. Article
  16. New and Emerging Biological Therapies for Myasthenia Gravis: A Focussed Review for Clinical Decision-Making.BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy · 2025
    Review
  17. Review
  18. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 7 institutions in 1 country.

Jan L De BleeckerDepartment of Neurology, University Hospital Ghent and AZ Sint-Lucas, Ghent, Belgium. jan.debleecker@ugent.be.ORCID http://orcid.org/0000-0002-1328-1812
Gauthier RemicheCentre de Référence Neuromusculaire, Department of Neurology, Hôpital Universitaire de Bruxelles (HUB)-Hôpital Erasme, Université Libre de Bruxelles (ULB), Brussels, Belgium.ORCID http://orcid.org/0000-0002-4882-3570
Alicia Alonso-JiménezDepartment of Neurology, Faculty of Medicine and Health Sciences, Antwerp University Hospital, Translational Neurosciences, UAntwerpen, Antwerp, Belgium.ORCID http://orcid.org/0000-0002-2200-9255
Vinciane Van ParysDepartment of Neurology, Cliniques Universitaires Saint-Luc, Université Catholique de Louvain (UCL), Brussels, Belgium.ORCID http://orcid.org/0000-0003-4741-123X
Véronique BissayVrije Universiteit Brussel, Universitair Ziekenhuis Brussel, NEUR Research Group and Department of Neurology, Brussels, Belgium.ORCID http://orcid.org/0000-0003-3832-8725
Stéphanie DelstancheUniversity Department of Neurology, CHR Citadelle, Liège, Belgium.ORCID http://orcid.org/0000-0003-4481-579X
Kristl G ClaeysDepartment of Neurology, University Hospitals Leuven, Leuven, Belgium.ORCID http://orcid.org/0000-0001-9937-443X
Centre hospitalier régional de la Citadelle · BECliniques Universitaires Saint-Luc · BEGhent University Hospital · BEUniversité Libre de Bruxelles · BEUniversity of Antwerp · BEVIB-KU Leuven Center for Brain & Disease Research · BEVrije Universiteit Brussel · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

International guidelines on the treatment of myasthenia gravis (MG) have been published but are not tailored to the Belgian situation. This publication presents recommendations from a group of Belgian MG experts for the practical management of MG in Belgium. It includes recommendations for treatment of adult patients with generalized myasthenia gravis (gMG) or ocular myasthenia gravis (oMG). Depending on the MG-related antibody a treatment sequence is suggested with therapies that can be added on if the treatment goal is not achieved. Selection of treatments was based on the level of evidence of efficacy, registration and reimbursement status in Belgium, common daily practice and the personal views and experiences of the authors. The paper reflects the situation in February 2024. In addition to the treatment considerations, other relevant aspects in the management of MG are addressed, including comorbidities, drugs aggravating disease symptoms, pregnancy, and vaccination. As many new treatments might potentially come to market, a realistic future perspective on the impact of these treatments on clinical practice is given. In conclusion, these recommendations intend to be a guide for neurologists treating patients with MG in Belgium.

Indexed as

Myasthenia GravisBelgiumDisease ManagementHumansPractice Guidelines as TopicBelgiumClinical managementMyasthenia gravisTherapiesTreatment recommendations

Identifiers

PMID38649556
PMCPMC11266451
OpenAlexW4394993446

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.