Evidence map›Paper›PMID 38649541›Full record

ArticleEuropean archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery2024

An in vitro model for postoperative cranial nerve dysfunction and a proposed method of rehabilitation with N-acetylcysteine microparticles.

Ashley Kita, Katherine Kedeshian, Michelle Hong, Larry Hoffman

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Ashley KitaDepartment of Head and Neck Surgery, David Geffen School of Medicine at University of California Los Angeles, 10883 Le Conte Avenue, CHS 63-170, Los Angeles, CA, 90095, USA. akita@mednet.ucla.edu.ORCID http://orcid.org/0000-0002-2759-8271
Katherine KedeshianDepartment of Head and Neck Surgery, David Geffen School of Medicine at University of California Los Angeles, 10883 Le Conte Avenue, CHS 63-170, Los Angeles, CA, 90095, USA.
Michelle HongDepartment of Head and Neck Surgery, David Geffen School of Medicine at University of California Los Angeles, 10883 Le Conte Avenue, CHS 63-170, Los Angeles, CA, 90095, USA.
Larry HoffmanDepartment of Head and Neck Surgery, David Geffen School of Medicine at University of California Los Angeles, 10883 Le Conte Avenue, CHS 63-170, Los Angeles, CA, 90095, USA.
University of California, Los Angeles · US

Funding

Prolonged Local Melatonin Delivery for Recurrent Laryngeal Nerve NeuropraxiaK08DC019957 · NIDCD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Ashley Kita · 2022 to 2026
$1.1M
NIDCD NIH HHS 1K08DC019957-01NIDCD NIH HHS K08 DC019957
6 · The paper itself

Abstract

purposeWhen operating near cranial motor nerves, transient postoperative weakness of target muscles lasting weeks to months is often observed. As nerves are typically intact at a procedure's completion, paresis is hypothesized to result from a combination of neurapraxia and axonotmesis. As both neurapraxia and axonotmesis involve Schwann cell injury and require remyelination, we developed an in vitro RSC96 Schwann cell model of injury using hydrogen peroxide (H

methodsThe concentration of H

results100 µM N-acetylcysteine improved the viability of Schwann cells dosed with H

conclusionWe developed a Schwann cell culture model of iatrogenic nerve injury and used this to identify N-acetylcysteine as an agent to promote recovery. N-acetylcysteine was packaged into microparticles and demonstrated promise as a locally administrable agent to reduce oxidative stress in Schwann cells.

Indexed as

AcetylcysteineHydrogen PeroxideOxidative StressSchwann CellsAnimalsAntioxidantsCell SurvivalCranial Nerve DiseasesMelatoninPostoperative ComplicationsRatsResveratrolAcetylcysteineAntioxidantsHydrogen PeroxideMelatoninResveratrolAxonotmesisDrug deliveryMicroparticlesNerve injuryNeurapraxiaSchwann cell

Identifiers

PMID38649541
PMCPMC11211122
OpenAlexW4395047599

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.