Evidence map›Paper›PMID 38649492›Full record

SynthesisSurgical endoscopy2024

Endoscopic incisional therapy for benign anastomotic strictures after esophagectomy or gastrectomy: a systematic review and meta-analysis.

Zaharadeen Jimoh, Uzair Jogiat, Alex Hajjar, Kevin Verhoeff, Simon Turner, Clarence Wong, Janice Y Kung, Eric L R Bédard

Abstract readSystematic ReviewMeta-Analysis
PubMed Publisher
In one paragraph

Synthesis in Surgical endoscopy, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.3field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 4 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Zaharadeen JimohFaculty of Nursing, University of Alberta, Edmonton, Canada.
Uzair JogiatDivision of Thoracic Surgery, Univesity of Alberta, Edmonton, AB, Canada. ujogiat@ualberta.ca.ORCID 0000-0001-5271-9381
Alex HajjarDivision of Thoracic Surgery, Univesity of Alberta, Edmonton, AB, Canada.
Kevin VerhoeffDivision of Thoracic Surgery, Univesity of Alberta, Edmonton, AB, Canada.
Simon TurnerDivision of Thoracic Surgery, Univesity of Alberta, Edmonton, AB, Canada.
Clarence WongDivision of Gastroenterology, Department of Medicine, University of Alberta, Edmonton, AB, Canada.
Janice Y KungGeoffrey & Robyn Sperber Health Sciences Library, University of Alberta, Edmonton, Canada.
Eric L R BédardDivision of Thoracic Surgery, Univesity of Alberta, Edmonton, AB, Canada.
University of Alberta · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundStudies have evaluated the efficacy of endoscopic incisional therapy (EIT) for benign anastomotic strictures. We performed a systematic review and meta-analysis to evaluate stricture recurrence after EIT following esophagectomy or gastrectomy.

methodsA systematic search of databases was performed up to April 2nd, 2023, after selection of key search terms with the research team. Inclusion criteria included human participants undergoing EIT for a benign anastomotic stricture after esophagectomy or gastrectomy, age ≥ 18, and n ≥ 5. Our primary outcome was the incidence of stricture recurrence among patients treated with EIT compared to dilation. Our secondary outcome was the stricture-free duration after EIT and rate of adverse events. Meta-analysis was performed with RevMan 5.4.1 using a Mantel-Haenszel random-effects model. Publication bias was evaluated with funnel plots and the Egger test.

resultsA total of 2550 unique preliminary studies underwent screening of abstracts and titles. This led to 33 studies which underwent full-text review and five studies met the inclusion criteria. Meta-analysis revealed reduced odds of overall stricture recurrence (OR 0.35, 95% CI 0.13-0.92, p = 0.03; I

conclusionCurrent data suggest EIT is associated with reduced odds of stricture recurrence among naïve anastomotic strictures. Large, prospective studies are needed to characterize the safety profile of EIT, address publication bias, and to explore multimodal therapies for refractory strictures.

Indexed as

Anastomosis, SurgicalEsophageal StenosisEsophagectomyGastrectomyPostoperative ComplicationsConstriction, PathologicDilatationHumansRecurrenceAnastomotic stricturesDilationEndoscopic incisional therapyEsophagectomyGastrectomy

Identifiers

PMID38649492
OpenAlexW4394996151

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.