ArticleScientific reports2024
Iron status and sarcopenia-related traits: a bi-directional Mendelian randomization study.
Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed, 9 citations in OpenAlex.
- Nutritional pathways from treatment to management of sarcopenia in patients with gastric cancer: a narrative review.Korean journal of family medicine · 2026Review
- Unveiling the Causal Relationship Between Osteoporosis and Circulating Metabolites from a Genetic Perspective.Journal of musculoskeletal & neuronal interactions · 2025Article
- Association of serum chitinase-3-like protein 1 with sarcopenia in patients with type 2 diabetes mellitus.Journal of endocrinological investigation · 2025Article
- Correlation between iron accumulation and sarcopenia in middle-aged and elderly populations.BMC musculoskeletal disorders · 2025Article
- Association of ultrasound signs of sarcopenia with serum ferritin levels and hepatic indices like NFS and FIB-4 in NAFLD patients.BMC gastroenterology · 2025Article
- Iron Status and Risk of Periodontitis and Dental Caries: A Mendelian Randomization Study.International dental journal · 2025Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
Abstract
Although serum iron status and sarcopenia are closely linked, the presence of comprehensive evidence to establish a causal relationship between them remains insufficient. The objective of this study is to employ Mendelian randomization techniques to clarify the association between serum iron status and sarcopenia. We conducted a bi-directional Mendelian randomization (MR) analysis to investigate the potential causal relationship between iron status and sarcopenia. MR analyses were performed using inverse variance weighted (IVW), MR-Egger, and weighted median methods. Additionally, sensitivity analyses were conducted to verify the reliability of the causal association results. Then, we harvested a combination of SNPs as an integrated proxy for iron status to perform a MVMR analysis based on IVW MVMR model. UVMR analyses based on IVW method identified causal effect of ferritin on appendicular lean mass (ALM, β = - 0.051, 95% CI - 0.072, - 0.031, p = 7.325 × 10
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.