Evidence map›Paper›PMID 38649186›Full record

ArticleLife science alliance2024

lncRNA LINC00941 modulates MTA2/NuRD occupancy to suppress premature human epidermal differentiation.

Eva Morgenstern, Carolin Molthof, Uwe Schwartz, Johannes Graf, Astrid Bruckmann, Sonja Hombach, Markus Kretz

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Life science alliance, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Eva MorgensternRegensburg Center for Biochemistry (RCB), University of Regensburg, Regensburg, Germany.ORCID 0009-0008-6430-5491
Carolin MolthofRegensburg Center for Biochemistry (RCB), University of Regensburg, Regensburg, Germany.
Uwe SchwartzNGS Analysis Center Biology and Pre-Clinical Medicine, University of Regensburg, Regensburg, Germany.ORCID 0000-0002-7628-2687
Johannes GrafRegensburg Center for Biochemistry (RCB), University of Regensburg, Regensburg, Germany.
Astrid BruckmannRegensburg Center for Biochemistry (RCB), University of Regensburg, Regensburg, Germany.ORCID 0000-0001-6082-2944
Sonja HombachRegensburg Center for Biochemistry (RCB), University of Regensburg, Regensburg, Germany.
Markus KretzRegensburg Center for Biochemistry (RCB), University of Regensburg, Regensburg, Germany markus.kretz@medicalschool-hamburg.de.ORCID 0000-0003-3420-3925
University of Regensburg · DEMSH Medical School Hamburg – University of Applied Sciences and Medical University · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Numerous long non-coding RNAs (lncRNAs) were shown to have a functional impact on cellular processes such as human epidermal homeostasis. However, the mechanism of action for many lncRNAs remains unclear to date. Here, we report that lncRNA LINC00941 regulates keratinocyte differentiation on an epigenetic level through association with the NuRD complex, one of the major chromatin remodelers in cells. We find that LINC00941 interacts with NuRD-associated MTA2 and CHD4 in human primary keratinocytes. LINC00941 perturbation changes MTA2/NuRD occupancy at bivalent chromatin domains in close proximity to transcriptional regulator genes, including the

Indexed as

Cell DifferentiationEpidermisHistone DeacetylasesKeratinocytesMi-2 Nucleosome Remodeling and Deacetylase ComplexRepressor ProteinsRNA, Long NoncodingCells, CulturedChromatinEarly Growth Response Protein 3Epidermal CellsEpigenesis, GeneticGene Expression RegulationHumansChromatinEarly Growth Response Protein 3EGR3 protein, humanHistone DeacetylasesMi-2 Nucleosome Remodeling and Deacetylase ComplexMTA2 protein, humanRepressor ProteinsRNA, Long Noncoding

Identifiers

PMID38649186
PMCPMC11035861
OpenAlexW4395011782

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.