Evidence map›Paper›PMID 38648925›Full record

ArticleNeuropharmacology2024

Acute nicotine activates orectic and inhibits anorectic brain regions in rats exposed to chronic nicotine.

Kokila Shankar, Sélène Bonnet-Zahedi, Kristel Milan, Andrea Ruiz D'argence, Elizabeth Sneddon, Ran Qiao, Supakorn Chonwattangul, Lieselot L G Carrette, Marsida Kallupi, Olivier George

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuropharmacology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.9field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 2 countries.

Kokila ShankarDepartment of Psychiatry, University of California San Diego School of Medicine, La Jolla, CA, 92093, USA.
Sélène Bonnet-ZahediDepartment of Psychiatry, University of California San Diego School of Medicine, La Jolla, CA, 92093, USA; Institut de Neurosciences de la Timone, Aix-Marseille Université, Marseille, 13005, France.
Kristel MilanDepartment of Psychiatry, University of California San Diego School of Medicine, La Jolla, CA, 92093, USA.
Andrea Ruiz D'argenceDepartment of Psychiatry, University of California San Diego School of Medicine, La Jolla, CA, 92093, USA.
Elizabeth SneddonDepartment of Psychiatry, University of California San Diego School of Medicine, La Jolla, CA, 92093, USA.
Ran QiaoDepartment of Psychiatry, University of California San Diego School of Medicine, La Jolla, CA, 92093, USA.
Supakorn ChonwattangulDepartment of Psychiatry, University of California San Diego School of Medicine, La Jolla, CA, 92093, USA.
Lieselot L G CarretteDepartment of Psychiatry, University of California San Diego School of Medicine, La Jolla, CA, 92093, USA.
Marsida KallupiDepartment of Psychiatry, University of California San Diego School of Medicine, La Jolla, CA, 92093, USA.
Olivier GeorgeDepartment of Psychiatry, University of California San Diego School of Medicine, La Jolla, CA, 92093, USA. Electronic address: olgeorge@health.ucsd.edu.
University of California San Diego · US

Funding

Single-cell whole brain imaging of nicotine intoxication, dependence, and abstinenceR21DA057694 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GEORGE, OLIVIER · 2023 to 2024
$435k
Investigation of how sex steroids and nicotinic acetylcholine receptors promote cocaine self-administration K00DA057923 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Elizabeth Sneddon · 2023 to 2026
$344k
NIDA NIH HHS K00 DA057923NIDA NIH HHS R21 DA057694
6 · The paper itself

Abstract

Nicotine use produces psychoactive effects, and chronic use is associated with physiological and psychological symptoms of addiction. However, chronic nicotine use is known to decrease food intake and body weight gain, suggesting that nicotine also affects central metabolic and appetite regulation. We recently showed that acute nicotine self-administration in nicotine-dependent animals produces a short-term increase in food intake, contrary to its long-term decrease of feeding behavior. As feeding behavior is regulated by complex neural signaling mechanisms, this study aimed to test the hypothesis that nicotine intake in animals exposed to chronic nicotine may increase activation of pro-feeding regions and decrease activation of pro-satiety regions to produce the acute increase in feeding behavior. FOS immunohistochemistry revealed that acute nicotine intake in nicotine self-administering animals increased activation of the pro-feeding arcuate and lateral hypothalamic nuclei and decreased activation of the pro-satiety parabrachial nucleus. Regional correlational analysis also showed that acute nicotine changes the functional connectivity of the hunger/satiety network. Further dissection of the role of the arcuate nucleus using electrophysiology found that putative POMC neurons in animals given chronic nicotine exhibited decreased firing following acute nicotine application. These brain-wide central signaling changes may contribute to the acute increase in feeding behavior we see in rats after acute nicotine and provide new areas of focus for studying both nicotine addiction and metabolic regulation.

Indexed as

BrainNicotineAnimalsAnorexiaEatingFeeding BehaviorMaleNeuronsNicotinic AgonistsPro-OpiomelanocortinProto-Oncogene Proteins c-fosRatsRats, Sprague-DawleySelf AdministrationNicotineNicotinic AgonistsPro-OpiomelanocortinProto-Oncogene Proteins c-fosArcuateFOSHypothalamusPOMCRodentSelf-administration

Identifiers

PMID38648925
PMCPMC11734747
OpenAlexW4394987936

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.