Evidence map›Paper›PMID 38648912›Full record

ArticleActa biomaterialia2024

In vivo micro-computed tomography evaluation of radiopaque, polymeric device degradation in normal and inflammatory environments.

Kendell M Pawelec, Jeremy M L Hix, Arianna Troia, Keith W MacRenaris, Matti Kiupel, Erik M Shapiro

Open access · greenAbstract read
In one paragraph

Article in Acta biomaterialia, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
4.6field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Kendell M PawelecDepartment of Radiology, Michigan State University, East Lansing, MI 48824, USA; Institute for Quantitative Health Sciences and Engineering, Michigan State University, East Lansing, MI 48824, USA. Electronic address: paweleck@msu.edu.
Jeremy M L HixDepartment of Radiology, Michigan State University, East Lansing, MI 48824, USA; Institute for Quantitative Health Sciences and Engineering, Michigan State University, East Lansing, MI 48824, USA.
Arianna TroiaDepartment of Radiology, Michigan State University, East Lansing, MI 48824, USA.
Keith W MacRenarisQuantitative Bio Element Analysis and Mapping (QBEAM) Center, Michigan State University, East Lansing, MI 48824, USA.
Matti KiupelDepartment of Pathobiology and Diagnostic Investigation, Michigan State University, East Lansing, MI 48824, USA.
Erik M ShapiroDepartment of Radiology, Michigan State University, East Lansing, MI 48824, USA; Institute for Quantitative Health Sciences and Engineering, Michigan State University, East Lansing, MI 48824, USA; Department of Physiology, Michigan State University, East Lansing, MI 48824, USA; Department of Chemical Engineering and Material Science, Michigan State University, East Lansing, MI 48824, USA; Department of Biomedical Engineering, Michigan State University, East Lansing, MI 48824, USA. Electronic address: shapir86@msu.edu.
Michigan State University · US

Funding

TR&D Project 3: Photoacoustic Detection of Metal Fluxes at the Tissue LevelP41GM135018 · NIGMS · NORTHWESTERN UNIVERSITY · PI MACRENARIS, KEITH W · 2020 to 2024
$5.8M
Radiopaque 3D printed tissue engineered scaffolds for nerve generationR01EB029418 · NIBIB · MICHIGAN STATE UNIVERSITY · PI Erik Shapiro · 2021 to 2026
$3.2M
Laser Ablation Inductively Coupled Plasma Time-of-Flight Mass Spectrometer for Advanced Bioelement Imaging ApplicationsS10OD026786 · OD · NORTHWESTERN UNIVERSITY · PI O'HALLORAN, THOMAS V · 2019 to 2019
$658k
NIBIB NIH HHS R01 EB029418NIGMS NIH HHS P41 GM135018NIH HHS S10 OD026786
6 · The paper itself

Abstract

Polymeric biomedical implants are an important clinical tool, but degradation remains difficult to determine post-implantation. Computed tomography (CT) could be a powerful tool for device monitoring, but polymers require incorporation of radiopaque contrast agents to be distinguishable from tissue. In addition, immune response to radiopaque devices must be characterized as it modulates device function. Radiopaque devices and films were produced by incorporating 0-20 wt% TaO

Indexed as

Contrast MediaInflammationX-Ray MicrotomographyAnimalsMacrophagesMiceMice, Inbred C57BLNanoparticlesPolyestersPolylactic Acid-Polyglycolic Acid CopolymerContrast MediapolycaprolactonePolyestersPolylactic Acid-Polyglycolic Acid CopolymerDegradationInflammationIn situ monitoringNanoparticles

Identifiers

PMID38648912
PMCPMC11144086
OpenAlexW4394988558

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.