Evidence map›Paper›PMID 38648470›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2024

Impact of repeated blast exposure on active-duty United States Special Operations Forces.

Natalie Gilmore, Chieh-En J Tseng, Chiara Maffei, Samantha L Tromly, Katryna B Deary, Isabella R McKinney, Jessica N Kelemen, Brian C Healy, Collin G Hu, Gabriel Ramos-Llordén and 20 more

Registry-linked trialOpen access · hybridAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07131475 (ReBlast Precision), which is not on this map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
9.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07131475 phase2recruitingnot on this mapstarted 2025, after this paper: background citation

ReBlast Precision (Precision Biomarkers to Detect Brain Injury in Active-Duty United States Special Operations Forces With Repeated Blast Exposure)

TypeinterventionalSponsorMassachusetts General HospitalRan2025 to 2029Enrolled100ConditionsBlast InjuryArmsPBR28 TSPO PET
3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

30 authors at 6 institutions in 1 country.

Natalie Gilmore *Center for Neurotechnology and Neurorecovery, Massachusetts General Hospital, Boston, MA 02114.ORCID 0000-0002-2935-8386
Chieh-En J Tseng *Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129.ORCID 0000-0003-0592-335X
Chiara Maffei *Center for Neurotechnology and Neurorecovery, Massachusetts General Hospital, Boston, MA 02114.
Samantha L TromlyInstitute of Applied Engineering, University of South Florida, Tampa, FL 33612.
Katryna B DearyNavy SEAL Foundation, Virginia Beach, VA 23455.ORCID 0009-0007-9738-5179
Isabella R McKinneyCenter for Neurotechnology and Neurorecovery, Massachusetts General Hospital, Boston, MA 02114.ORCID 0009-0007-8105-4674
Jessica N KelemenCenter for Neurotechnology and Neurorecovery, Massachusetts General Hospital, Boston, MA 02114.
Brian C HealyHarvard T.H. Chan School of Public Health, Boston, MA 02115.
Collin G HuUnited States Army Special Operations Aviation Command, Fort Liberty, NC 28307.
Gabriel Ramos-LlordénDepartment of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129.
Maryam MasoodCenter for Neurotechnology and Neurorecovery, Massachusetts General Hospital, Boston, MA 02114.ORCID 0000-0002-1534-8830
Ryan J CaliCenter for Neurotechnology and Neurorecovery, Massachusetts General Hospital, Boston, MA 02114.
Jennifer GuoDepartment of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114.
Heather G BelangerDepartment of Psychiatry and Behavioral Neurosciences, University of South Florida, Tampa, FL 33613.ORCID 0000-0002-3181-7473
Eveline F YaoOffice of the Air Force Surgeon General, Falls Church, VA 22042.
Timothy BaxterInstitute of Applied Engineering, University of South Florida, Tampa, FL 33612.
Bruce FischlDepartment of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129.ORCID 0000-0002-2413-1115
Andrea S FoulkesHarvard T.H. Chan School of Public Health, Boston, MA 02115.
Jonathan R PolimeniDepartment of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129.
Bruce R RosenDepartment of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129.
Daniel P PerlDepartment of Pathology, F. Edward Hébert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD 20814.ORCID 0000-0002-4869-924X
Jacob M HookerDepartment of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129.ORCID 0000-0002-9394-7708
Nicole R ZürcherDepartment of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129.ORCID 0000-0003-0271-6304
Susie Y HuangDepartment of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129.
W Taylor KimberlyDepartment of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114.ORCID 0000-0002-2519-8530
Douglas N GreveDepartment of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129.ORCID 0000-0002-0610-0155
Christine L Mac DonaldDepartment of Neurological Surgery, University of Washington, Seattle, WA 98195.ORCID 0000-0002-7419-996X
Kristen Dams-O'ConnorDepartment of Rehabilitation and Human Performance, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
Yelena G Bodien *Center for Neurotechnology and Neurorecovery, Massachusetts General Hospital, Boston, MA 02114.
Brian L Edlow *Center for Neurotechnology and Neurorecovery, Massachusetts General Hospital, Boston, MA 02114.ORCID 0000-0001-7235-8456
Harvard University · USUniversity of South Florida · USUniformed Services University of the Health Sciences · USIcahn School of Medicine at Mount Sinai · USRational Biotechnology (United States) · USUniversity of Washington · US

Funding

U.S. Department of Defense (DOD) USSOCOM Contract No. H9240520D0001
6 · The paper itself

Abstract

United States (US) Special Operations Forces (SOF) are frequently exposed to explosive blasts in training and combat, but the effects of repeated blast exposure (RBE) on SOF brain health are incompletely understood. Furthermore, there is no diagnostic test to detect brain injury from RBE. As a result, SOF personnel may experience cognitive, physical, and psychological symptoms for which the cause is never identified, and they may return to training or combat during a period of brain vulnerability. In 30 active-duty US SOF, we assessed the relationship between cumulative blast exposure and cognitive performance, psychological health, physical symptoms, blood proteomics, and neuroimaging measures (Connectome structural and diffusion MRI, 7 Tesla functional MRI, [

Indexed as

Blast InjuriesMilitary PersonnelAdultBrainCognitionFemaleHumansMagnetic Resonance ImagingMalePositron-Emission TomographyUnited StatesYoung Adultblast overpressureSpecial Operations Forcestraumatic brain injury

Identifiers

PMID38648470
PMCPMC11087753
OpenAlexW4394993662

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.