Evidence map›Paper›PMID 38648272›Full record

ArticleCirculation2024

Autonomic Dysfunction Linked to Inhibition of the Na

Christopher P Regan, Pierre Morissette, Richard L Kraus, Erjia Wang, Leticia Arrington, Marissa Vavrek, Jan de Hoon, Marleen Depre, Thomas Lodeweyck, Ignace Demeyer and 3 more

Abstract readLetter
In one paragraph

Article in Circulation, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Antigen-Detected NMR for Minimal Epitope Engineering and Structure-Guided Selection of a NaAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  2. A neurocutaneous NaScience advances · 2026
    Article
  3. Review
  4. Article
  5. Review
  6. Review
  7. An approach to targeting Nav1.7 for pain sensations.The Journal of clinical investigation · 2025
    Article
  8. Review
  9. Article
  10. Article
  11. Mechanism-based nonopioid analgesic targets.The Journal of clinical investigation · 2025
    Review
  12. Refining the NaFEBS letters · 2025
    Article
  13. Review
  14. Review
  15. Article
  16. The genetics of pain.BJA education · 2024
    Review
  17. Article
  18. Sodium channels NaNeurobiology of pain (Cambridge, Mass.)
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Christopher P Regan *Nonclinical Drug Safety (C.P.R., P.M., E.W.), Merck & Co., Inc., West Point, PA.ORCID 0000-0002-3201-5878
Pierre Morissette *Nonclinical Drug Safety (C.P.R., P.M., E.W.), Merck & Co., Inc., West Point, PA.ORCID 0009-0000-4906-4716
Richard L KrausNeuroscience (R.L.K.), Merck & Co., Inc., West Point, PA.ORCID 0000-0002-3250-3812
Erjia WangNonclinical Drug Safety (C.P.R., P.M., E.W.), Merck & Co., Inc., West Point, PA.
Leticia ArringtonPharmacokinetics, Pharmacodynamics and Drug Metabolism (L.A., M.V.), Merck & Co., Inc., West Point, PA.ORCID 0000-0001-7272-1657
Marissa VavrekPharmacokinetics, Pharmacodynamics and Drug Metabolism (L.A., M.V.), Merck & Co., Inc., West Point, PA.ORCID 0000-0003-0240-2583
Jan de HoonCenter for Clinical Pharmacology, Department of Pharmaceutical and Pharmacological Sciences, University of Leuven; Belgium (J.d.H., M.D., T. Lodeweyck).
Marleen DepreCenter for Clinical Pharmacology, Department of Pharmaceutical and Pharmacological Sciences, University of Leuven; Belgium (J.d.H., M.D., T. Lodeweyck).ORCID 0009-0005-1318-6574
Thomas LodeweyckCenter for Clinical Pharmacology, Department of Pharmaceutical and Pharmacological Sciences, University of Leuven; Belgium (J.d.H., M.D., T. Lodeweyck).ORCID 0000-0002-6137-7931
Ignace DemeyerBurn Center, Military Hospital Queen Astrid, Brussels, Belgium (I.D.).ORCID 0009-0008-0294-2460
Tine LaethemTranslational Medicine, Merck & Co., Inc., Upper Gwynedd, PA (T. Laethem, A. Stoch, A. Struyk).
Aubrey StochTranslational Medicine, Merck & Co., Inc., Upper Gwynedd, PA (T. Laethem, A. Stoch, A. Struyk).
Arie StruykTranslational Medicine, Merck & Co., Inc., Upper Gwynedd, PA (T. Laethem, A. Stoch, A. Struyk).ORCID 0000-0003-0189-1004

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

NAV1.7 Voltage-Gated Sodium ChannelAutonomic Nervous System DiseasesHumansMaleSodium Channel BlockersVoltage-Gated Sodium Channel BlockersNAV1.7 Voltage-Gated Sodium ChannelSCN9A protein, humanSodium Channel BlockersVoltage-Gated Sodium Channel Blockersbaroreflexclinical studyheart rate controlNAV1.7 voltage-gated sodium channelpain

Identifiers

PMID38648272
PMCPMC11027978

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.