ArticleeLife2024
Membrane-bound
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Article in eLife, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 7 citations in OpenAlex.
- Hepatic Lipoprotein Production, Cardiometabolic Phenotypes, and Subtypes of Steatotic Liver Disease.Circulation research · 2026Review
- Genetic and lifestyle determinants of lipid profiles in Japanese young adults: evidence from MBOAT7 rs641738.Lipids in health and disease · 2026Article
- Targeting the LPI/GPR55 Axis in MAFLD and MASH: Novel Insights, Therapeutic Strategies and Future Directions.Liver international : official journal of the International Association for the Study of the Liver · 2026Review
- Biomarkers for early identification of metabolic dysfunction-associated steatotic liver disease (MASLD): a narrative review.Archives of medical science : AMS · 2026Article
- Kaempferol Remodels Liver Monocyte Populations and Treats Hepatic Fibrosis in Mice by Modulating Intestinal Flora and Metabolic Reprogramming.Inflammation · 2025Article
- Bridging the gap in obesity research: A consensus statement from the European Society for Clinical Investigation.European journal of clinical investigation · 2025Review
- Hepatic lipid remodeling in cold exposure uncovers direct regulation of bis(monoacylglycero)phosphate lipids by phospholipase A2 group XV.Cell metabolism · 2025Article
- Metabolic and genetic mechanisms of metabolic dysfunction-associated steatotic liver disease: an integrative perspective from molecular pathways to clinical challenges.Frontiers in endocrinology · 2025Review
- Steatotic liver disease and cancer: from pathogenesis to therapeutic targets.eGastroenterology · 2025Review
- Immunological dynamics in MASH: from landscape analysis to therapeutic intervention.Journal of gastroenterology · 2024Review
- Gut-liver axis: Recent concepts in pathophysiology in alcohol-associated liver disease.Hepatology (Baltimore, Md.) · 2024Review
- Phospholipid Acyltransferases: Characterization and Involvement of the Enzymes in Metabolic and Cancer Diseases.Cancers · 2024Review
Corrections and comments
- Update of
Authors and funding
24 authors at 5 institutions in 1 country.
Venkateshwari VaradharajanDepartment of Cancer Biology, Lerner Research Institute of the Cleveland Clinic, Cleveland, United States.ORCID https://orcid.org/0000-0002-4557-9840
Iyappan RamachandiranDepartment of Cancer Biology, Lerner Research Institute of the Cleveland Clinic, Cleveland, United States.
William J MasseyDepartment of Cancer Biology, Lerner Research Institute of the Cleveland Clinic, Cleveland, United States.ORCID https://orcid.org/0000-0002-2087-6048
Raghav JainDepartment of Biochemistry, University of Wisconsin-Madison, Madison, United States.ORCID https://orcid.org/0000-0002-1284-6762
Rakhee BanerjeeDepartment of Cancer Biology, Lerner Research Institute of the Cleveland Clinic, Cleveland, United States.
Anthony J HorakDepartment of Cancer Biology, Lerner Research Institute of the Cleveland Clinic, Cleveland, United States.
Megan R McMullenNorthern Ohio Alcohol Center (NOAC), Lerner Research Institute, Cleveland Clinic, Cleveland, United States.
Emily HuangNorthern Ohio Alcohol Center (NOAC), Lerner Research Institute, Cleveland Clinic, Cleveland, United States.
Annette BellarNorthern Ohio Alcohol Center (NOAC), Lerner Research Institute, Cleveland Clinic, Cleveland, United States.
Shuhui W LorkowskiDepartment of Cardiovascular and Metabolic Sciences, Lerner Research Institute of the Cleveland Clinic, Cleveland, United States.
Kailash GulshanCenter for Gene Regulation in Health and Disease (GRHD), Cleveland State University, Cleveland, United States.
Robert N HelsleyDepartment of Cancer Biology, Lerner Research Institute of the Cleveland Clinic, Cleveland, United States.ORCID https://orcid.org/0000-0001-5000-3187
Isabella JamesDepartment of Biochemistry, University of Wisconsin-Madison, Madison, United States.ORCID https://orcid.org/0009-0000-2796-3497
Vai PathakNorthern Ohio Alcohol Center (NOAC), Lerner Research Institute, Cleveland Clinic, Cleveland, United States.
Jaividhya DasarathyNorthern Ohio Alcohol Center (NOAC), Lerner Research Institute, Cleveland Clinic, Cleveland, United States.
Nicole WelchNorthern Ohio Alcohol Center (NOAC), Lerner Research Institute, Cleveland Clinic, Cleveland, United States.
Srinivasan DasarathyCenter for Microbiome and Human Health, Lerner Research Institute, Cleveland Clinic, Cleveland, United States.ORCID https://orcid.org/0000-0003-1774-0104
David StreemLutheran Hospital, Cleveland Clinic, Cleveland, United States.
Ofer ReizesCenter for Microbiome and Human Health, Lerner Research Institute, Cleveland Clinic, Cleveland, United States.
Daniela S AllendeNorthern Ohio Alcohol Center (NOAC), Lerner Research Institute, Cleveland Clinic, Cleveland, United States.
Jonathan D SmithDepartment of Cancer Biology, Lerner Research Institute of the Cleveland Clinic, Cleveland, United States.ORCID https://orcid.org/0000-0002-0415-386X
Judith SimcoxDepartment of Biochemistry, University of Wisconsin-Madison, Madison, United States.ORCID https://orcid.org/0000-0001-7350-6342
Laura E NagyCenter for Microbiome and Human Health, Lerner Research Institute, Cleveland Clinic, Cleveland, United States.
J Mark BrownCenter for Microbiome and Human Health, Lerner Research Institute, Cleveland Clinic, Cleveland, United States.ORCID https://orcid.org/0000-0003-2708-7487
Cleveland Clinic Lerner College of Medicine · USUniversity of Wisconsin–Madison · USCleveland Clinic · USCleveland State University · USUniversity of Kentucky · US
Funding
Kentucky Center for Clinical and Translational ScienceUL1TR001998 · NCATS · UNIVERSITY OF KENTUCKY · PI HARTMANN, KATHERINE E, KERN, PHILIP A · 2016 to 2025
$34.2MProject Two - Exercise Training Decreases Alcohol Drinking by an FGF21-Dependent MechanismP50AA024333 · NIAAA · CLEVELAND CLINIC LERNER COM-CWRU · PI LAURA E. NAGY · 2016 to 2026
$19.6MProject 3: Microbiota generated aryl sulfates and secondary bile acids in cardiometabolic diseaseP01HL147823 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI Zeneng Wang · 2019 to 2026
$17.0MThe Cleveland Digestive Diseases Research Core Center (DDRCC)P30DK097948 · NIDDK · CASE WESTERN RESERVE UNIVERSITY · PI AMITABH CHAK · 2015 to 2026
$15.6MMechanism of ApoA1 Lipidation by ABCA1 in HDL biogenesisR01HL128268 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI SMITH, JONATHAN D · 2016 to 2023
$3.5MPhosphatidylinositol Metabolism and Trafficking in Atherosclerosis and InflammationR01HL148158 · NHLBI · CLEVELAND STATE UNIVERSITY · PI Kailash Gulshan · 2020 to 2026
$3.1MMetaorganismal Endocrinology in Cardiometabolic DiseaseR01DK130227 · NIDDK · CLEVELAND CLINIC LERNER COM-CWRU · PI Jonathan Mark Brown · 2021 to 2026
$2.8MDark GPCR signaling underlying the Microbiome-Gut-Brain Axis for Alzheimer's Disease and Related DementiaRF1NS133812 · NINDS · CLEVELAND CLINIC LERNER COM-CWRU · PI BROWN, JONATHAN MARK, CHENG, FEIXIONG · 2023 to 2023
$2.3MAlcoholic Hepatitis Consortia: an intramural/extramural collaboration to unravel genetic determinantsU01AA026264 · NIAAA · CLEVELAND CLINIC LERNER COM-CWRU · PI BATALLER, RAMON, NAGY, LAURA E. · 2017 to 2022
$2.0MThe Role of Bacterial Choline Metabolism in Host Stress ResponsesR01DK120679 · NIDDK · CLEVELAND CLINIC LERNER COM-CWRU · PI BROWN, JONATHAN MARK · 2019 to 2022
$1.6MDiscovery and characterization of a novel acylcarnitine transporter in brown adipocytesR01DK133479 · NIDDK · UNIVERSITY OF WISCONSIN-MADISON · PI Judith Anne Simcox · 2022 to 2026
$1.5MMicrobial metabolites and Innate Immunity in AH: Biomarkers of injury and repairU01AA026938 · NIAAA · CLEVELAND CLINIC LERNER COM-CWRU · PI NAGY, LAURA E. · 2018 to 2023
$1.4MNCATS NIH HHS UL1 TR001998NHLBI NIH HHS P01 HL147823NHLBI NIH HHS R01 HL128268NHLBI NIH HHS R01 HL148158NIAAA NIH HHS P50 AA024333NIAAA NIH HHS U01 AA026264NIAAA NIH HHS U01 AA026938NIDDK NIH HHS K01 DK128022NIDDK NIH HHS P30 DK097948NIDDK NIH HHS R01 DK120679NIDDK NIH HHS R01 DK130227NIDDK NIH HHS R01 DK133479NINDS NIH HHS RF1 NS133812
Abstract
Recent genome-wide association studies (GWAS) have identified a link between single-nucleotide polymorphisms (SNPs) near the MBOAT7 gene and advanced liver diseases. Specifically, the common MBOAT7 variant (rs641738) associated with reduced MBOAT7 expression is implicated in non-alcoholic fatty liver disease (NAFLD), alcohol-associated liver disease (ALD), and liver fibrosis. However, the precise mechanism underlying MBOAT7-driven liver disease progression remains elusive. Previously, we identified MBOAT7-driven acylation of lysophosphatidylinositol lipids as key mechanism suppressing the progression of NAFLD (Gwag et al., 2019). Here, we show that MBOAT7 loss of function promotes ALD via reorganization of lysosomal lipid homeostasis. Circulating levels of MBOAT7 metabolic products are significantly reduced in heavy drinkers compared to healthy controls. Hepatocyte- (
Indexed as
AcyltransferasesHomeostasisLipid MetabolismLiver Diseases, AlcoholicLysosomesMembrane ProteinsAnimalsHepatocytesHumansLiverMaleMiceMice, Inbred C57BLMice, KnockoutAcyltransferasesMBOAT7 protein, humanMboat7 protein, mouseMembrane Proteinsalcohol-associated liver diseaseautophagyMBOAT7medicinemouse
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Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.