ArticlePsychosomatic medicine
Perceived Stress, Blood Biomarkers, and Cognitive Functioning in Older Adults.
Article in Psychosomatic medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed, 2 citations in OpenAlex.
- Association between psychiatric symptoms with multiple peripheral blood sample test: a 10-year retrospective study.Frontiers in psychiatry · 2024Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
introductionThere is a substantial gap in knowledge regarding how perceived stress may influence the relationship between serum-measured biomarkers for Alzheimer's disease and cognitive decline.
methodsThis study consists of 1118 older adult participants from the Chicago Health and Aging Project (CHAP) (60% Black participants and 63% female participants). Linear mixed effects regression models were conducted to examine the role of perceived stress in the association between three blood biomarkers: total tau (t-tau), glial fibrillary acid protein (GFAP), and neurofilament light chain (NfL) on global cognitive decline. Stratified analysis by stress level was also conducted to evaluate the associations between each blood biomarker and baseline cognitive function and decline. All models adjusted for age, race, sex, education, time, and their interactions with time.
resultsThe interaction of stress, NfL concentration, and time was statistically significant on global cognition ( β = -0.064 [SE = 0.028], p = .023) and on episodic memory ( β = -0.097 [SE = 0.036], p = .007).
conclusionsGreater stress level worsens the association between high NfL concentration and cognitive decline. Stress management interventions may be helpful to reduce the rate of cognitive decline in individuals with high concentrations of NfL.
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Registered trials
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