Evidence map›Paper›PMID 38647962›Full record

ArticleJournal of fluorescence2025

Development of a Coumarin-derived Fluorescent Probe for Detection of HOCl and its Application in Cells and Zebrafish.

Xin Chen, Jie Chen, Shanshan Wang, Shihua Yu, Zhigang Liu, Xiaodan Zeng

Abstract read
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In one paragraph

Article in Journal of fluorescence, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Xin ChenSchool of Chemical and Pharmaceutical Engineering, Jilin Institute of Chemical Technology, Jilin, People's Republic of China.
Jie ChenCenter of Characterization and Analysis, Jilin Institute of Chemical Technology, Jilin, People's Republic of China.
Shanshan WangCenter of Characterization and Analysis, Jilin Institute of Chemical Technology, Jilin, People's Republic of China.
Shihua YuSchool of Chemical and Pharmaceutical Engineering, Jilin Institute of Chemical Technology, Jilin, People's Republic of China.
Zhigang LiuCenter of Characterization and Analysis, Jilin Institute of Chemical Technology, Jilin, People's Republic of China. lzg@jlict.edu.cn.
Xiaodan ZengCenter of Characterization and Analysis, Jilin Institute of Chemical Technology, Jilin, People's Republic of China. jiangzxd@163.com.

Funding

Jilin Provincial Department of Science and Technology 20220203020SFNational Natural Science Foundation of China 22106051National Natural Science Foundation of China 51902125
6 · The paper itself

Abstract

We have prepared a simple, universal and efficient coumarin-derived fluorescent probe (XDS1) to detecting HOCl. The experimental findings revealed that the introduction of HOCl produced an obvious quenching effect on the probe with high selectivity and sensitivity. The calculated limit of detection (LOD) was as low as 0.02 μM. Furthermore, an impressive response time of less than 10 s was observed when XDS1 detecting HOCl. Importantly, the probe XDS1 exhibited negligible cytotoxicity, thereby facilitating its application for imaging HOCl within biological environment. The probe XDS1 had been successfully used for specific detection in cells.

Indexed as

CoumarinsFluorescent DyesHypochlorous AcidAnimalsHeLa CellsHumansLimit of DetectionMolecular StructureOptical ImagingSpectrometry, FluorescenceZebrafishcoumarinCoumarinsFluorescent DyesHypochlorous AcidBioimagingCoumarinFluorescent probeHOCl

Identifiers

PMID38647962

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.