ArticleBioresources and bioprocessing2024
In vitro study on antioxidant and lipid-lowering activities of tobacco polysaccharides.
Article in Bioresources and bioprocessing, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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10 citing papers in PubMed, 18 citations in OpenAlex.
- A Triterpenoid-Enriched GLE70 Fraction FromFood science & nutrition · 2026Article
- Research on the ultrasonic-assisted extraction, purification, structural characterization, and anti- glycolipid metabolic disorder (anti-GLMD) activity and mechanism of polysaccharide from Dryopteridis crassirhizomatis Rhizoma.Ultrasonics sonochemistry · 2026Article
- Mechanisms and structure-activity relationship of hypolipidemic effects of polysaccharides from natural resources: a review.Archives of pharmacal research · 2026Review
- Structural Characterization, Constipation-Relieving, and Hypolipidemic Activity of Polysaccharides from Fresh and ProcessedFoods (Basel, Switzerland) · 2026Article
- Antioxidant and Hypoglycemic Activity of Polysaccharides With Different Tissues From Rosa roxburghii f. eseiosa Ku.Chemistry & biodiversity · 2026Article
- Preparation and analysis of tobacco glycosides, and the relationship between glycoside aglycones and pyrolysis products: a review.Frontiers in molecular biosciences · 2026Review
- Selenium-Enriched Submerged Fermentation ofFood science & nutrition · 2025Article
- Structural Characterization of Polysaccharide fromFoods (Basel, Switzerland) · 2025Article
- A Study on the Extraction, Fermentation Condition Optimization, and Antioxidant Activity Assessment of Polysaccharides Derived fromFoods (Basel, Switzerland) · 2025Article
- Preparation and characterization of Tobacco polysaccharides and its modulation on hyperlipidemia in high-fat-diet-induced mice.Scientific reports · 2024Article
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9 authors at 2 institutions in 1 country.
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Abstract
Tobacco polysaccharides were extracted by hot water extraction, and purified and separated using DEAE-52 cellulose chromatography columns, and three purified polysaccharide fractions, YCT-1, YCT-2, and YCT-3, were finally obtained. The physicochemical properties of the three fractions were analyzed by ultraviolet spectroscopy, high-performance liquid chromatography and high-performance gel chromatography. The in vitro antioxidant activity of tobacco polysaccharides was compared among different fractions by using DPPH radical, hydroxyl radical scavenging assay and potassium ferricyanide method. The in vitro hypoglycemic activity was compared using α-amylase and α-glucosidase activity inhibition assay. And the in vitro hypolipidemic activity were investigated by using pancreatic lipase activity inhibition assay and HepG-2 intracellular lipid accumulation assay. All the results showed that the constituent monosaccharides of the three tobacco polysaccharide fractions were similar, but the molar percentages of each monosaccharide were different. The average molecular weights of the three components were 27,727 Da, 27,587 Da, and 66,517 Da, respectively, and the scavenging activities on DPPH radicals and hydroxyl radicals were at a high level with good quantitative-effect relationships. The reducing power were much lower than that of the positive control VC, and the three polysaccharide fractions had a weak inhibitory ability on α-amylase activity, but showed excellent inhibitory ability on α-glucosidase and pancreatic lipase activity. In addition, the results of cellular experiments showed that all three fractions were able to inhibit lipid over-accumulation in HepG-2 cells by increasing the mRNA expression levels of PPAR-α, CPT-1A, and CYP7A1 genes, and the tobacco polysaccharide YCT-3 showed the best effect. The mechanism by which YCT-3 ameliorated the over-accumulation of intracellular lipids in HepG-2 cells was found to be related to its influence on the expression of miR-155-3p and miR-17-3p in the exosomes of HepG-2 cells.
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