Construction and optimization of a biocatalytic route for the synthesis of neomenthylamine from menthone.

Hui-Jue Zhu, Jiang Pan, Chun-Xiu Li, Fei-Fei Chen, Jian-He Xu

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Article in Bioresources and bioprocessing, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed

0.2field-weighted citation impact, top 40% of its field

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5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Hui-Jue ZhuLaboratory of Biocatalysis and Synthetic Biotechnology, State Key Laboratory of Bioreactor Engineering, Shanghai Collaborative Innovation Centre for Biomanufacturing, College of Biotechnology, East China University of Science and Technology, Shanghai, 200237, People's Republic of China.

Jiang PanLaboratory of Biocatalysis and Synthetic Biotechnology, State Key Laboratory of Bioreactor Engineering, Shanghai Collaborative Innovation Centre for Biomanufacturing, College of Biotechnology, East China University of Science and Technology, Shanghai, 200237, People's Republic of China.

Chun-Xiu LiLaboratory of Biocatalysis and Synthetic Biotechnology, State Key Laboratory of Bioreactor Engineering, Shanghai Collaborative Innovation Centre for Biomanufacturing, College of Biotechnology, East China University of Science and Technology, Shanghai, 200237, People's Republic of China.

Fei-Fei ChenLaboratory of Biocatalysis and Synthetic Biotechnology, State Key Laboratory of Bioreactor Engineering, Shanghai Collaborative Innovation Centre for Biomanufacturing, College of Biotechnology, East China University of Science and Technology, Shanghai, 200237, People's Republic of China. feifeichen@mail.ecust.edu.cn.

Jian-He XuLaboratory of Biocatalysis and Synthetic Biotechnology, State Key Laboratory of Bioreactor Engineering, Shanghai Collaborative Innovation Centre for Biomanufacturing, College of Biotechnology, East China University of Science and Technology, Shanghai, 200237, People's Republic of China. jianhexu@ecust.edu.cn.ORCID http://orcid.org/0000-0003-4301-7630

East China University of Science and Technology · CN

Funding

Fundamental Research Funds for the Central Universities 222201714026National Key Research and Development Program of China 2019YFA0905000National Key Research and Development Program of China 2021YFA0911400National Natural Science Foundation of China 21871085National Natural Science Foundation of China 31971380

6 · The paper itself

Abstract

(+)-Neomenthylamine is an important industrial precursor used to synthesize high value-added chemicals. Here, we report a novel biocatalytic route to synthesize (+)-neomenthylamine by amination of readily available (-)-menthone substrate using ω-transaminase. By screening a panel of ω-transaminases, an ω-transaminase from Vibrio fluvialis JS17 was identified with considerable amination activity to (-)-menthone, and then characterization of enzymatic properties was conducted for the enzyme. Under optimized conditions, 10 mM (-)-menthone was transformed in a mild aqueous phase with 4.7 mM product yielded in 24 h. The biocatalytic route using inexpensive starting materials (ketone substrate and amino donor) and mild reaction conditions represents an easy and green approach for (+)-neomenthylamine synthesis. This method underscores the potential of biocatalysts in the synthesis of unnatural terpenoid amine derivatives.

Indexed as

Asymmetric synthesisBiocatalysis(+)-N-Boc-Neomenthylamine(+)-NeomenthylamineTransaminase

Identifiers

PMID38647910

DOI10.1186/s40643-023-00693-w

PMCPMC10992614

OpenAlexW4388303504

What OpenQuestion holds

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LicenceCC BY

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.