Evidence map›Paper›PMID 38647871›Full record

ArticleBioresources and bioprocessing2022

Minos and Restless transposon insertion mutagenesis of psychrotrophic fungus for red pigment synthesis adaptive to normal temperature.

Fengning Lu, Yanna Ren, Lulu Ding, Jian Lu, Xiangshan Zhou, Haifeng Liu, Nengfei Wang, Menghao Cai

Erratum issuedOpen access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioresources and bioprocessing, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Fengning LuState Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, 200237, China.
Yanna RenState Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, 200237, China.
Lulu DingState Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, 200237, China.
Jian LuState Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, 200237, China.
Xiangshan ZhouChina Resources Biopharmaceutical Co., Ltd, Unit 601, Building No. 2, YESUN Intelligent Community III, Guanlan Street, Shenzhen, China.
Haifeng LiuChina Resources Angde Biotech Pharma Co., Ltd, 78 E-Jiao Street, Liaocheng, 252201, Shandong, China.
Nengfei WangFirst Institute of Oceanography, Ministry of Natural Resources, Qingdao, 266061, China.
Menghao CaiState Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, 200237, China. 15026455240@163.com.ORCID http://orcid.org/0000-0001-6225-8515
East China University of Science and Technology · CNChina Resources (China) · CNMinistry of Natural Resources · CN

Funding

Fundamental Research Funds for Central Universities of the Central South University JKF01221628National Key R&D Program of China 2018YFC1406706the National Natural Science Foundation of China 42176238
6 · The paper itself

Abstract

The polar psychrotrophic fungus Geomyces sp. WNF-15A can produce high-quality natural red pigment for the potential use as edible pigment. However, it shows low-temperature-dependent synthesis of red pigment, which limits its large-scale industrial applications due to the difficult and high-cost bioprocess control. This study aims to develop transposon-mediated mutagenesis methods to generate mutants that are able to synthesize red pigment at normal temperature. Four transposable systems, including single and dual transposable systems, were established in this fungus based on the Minos from Drosophila hydei and the Restless from Tolypocladium inflatum. A total of 23 production-dominant mutants and 12 growth-dominant mutants were thus obtained by constructed transposable systems. At 14 °C and 20 °C, the MPS1 mutant strain achieved the highest level of red pigment (OD

Indexed as

Geomyces sp.Polar fungiPsychrotrophRed pigmentTransposon mutagenesis

Identifiers

PMID38647871
PMCPMC10992017
OpenAlexW4308340185

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.