ArticleBioresources and bioprocessing2022
A novel thermophilic chitinase directly mined from the marine metagenome using the deep learning tool Preoptem.
Article in Bioresources and bioprocessing, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 40 citations in OpenAlex.
- Advances in polyethylene biodegradation and bioconversion: Microbial, enzymatic, and biotechnological insights.Engineering microbiology · 2026Review
- Green bioconversion of insoluble chitin: chitinase development pathways via multi-strategy synergy.Bioresources and bioprocessing · 2026Review
- Machine learning for enzyme catalytic activity: current progress and future horizons.Briefings in bioinformatics · 2026Review
- Deep Learning-Based Prediction of Enzyme Optimal pH and Design of Point Mutations to Improve Acid Resistance.ACS synthetic biology · 2025Article
- Machine learning-guided discovery of thermophilic carbonic anhydrases from environmental metagenomes.Scientific reports · 2025Article
- Green Processes for Chitin and Chitosan Production from Insects: Current State, Challenges, and Opportunities.Polymers · 2025Review
- A Low-Temperature-Active Pectate Lyase from a Marine Bacterium for Orange Juice Clarification.Microorganisms · 2025Article
- Seq2Topt: a sequence-based deep learning predictor of enzyme optimal temperature.Briefings in bioinformatics · 2025Article
- Mining and rational design of psychrophilic catalases using metagenomics and deep learning models.Applied microbiology and biotechnology · 2024Article
- Heterologous Expression and Characterization of a pH-Stable Chitinase fromMarine drugs · 2024Article
- Enhancing the endo-activity of the thermophilic chitinase to yield chitooligosaccharides with high degrees of polymerization.Bioresources and bioprocessing · 2024Article
- Microbial-derived salt-tolerant proteases and their applications in high-salt traditional soybean fermented foods: a review.Bioresources and bioprocessing · 2023Review
- Data-driven strategies for the computational design of enzyme thermal stability: trends, perspectives, and prospects.Acta biochimica et biophysica Sinica · 2023Review
- Learning deep representations of enzyme thermal adaptation.Protein science : a publication of the Protein Society · 2022Article
- Insecticidal Activity of Chitinases fromToxins · 2022Article
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
Abstract
Chitin is abundant in nature and its degradation products are highly valuable for numerous applications. Thermophilic chitinases are increasingly appreciated for their capacity to biodegrade chitin at high temperatures and prolonged enzyme stability. Here, using deep learning approaches, we developed a prediction tool, Preoptem, to screen thermophilic proteins. A novel thermophilic chitinase, Chi304, was mined directly from the marine metagenome. Chi304 showed maximum activity at 85 ℃, its T
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