Evidence map›Paper›PMID 38647601›Full record

ArticleBioresources and bioprocessing2023

Anti-vibriosis bioactive molecules from Arctic Penicillium sp. Z2230.

Jiacheng Guo, Jin Yang, Pei Wang, Bo Guo, Huifang Li, Di Zhang, Faliang An, Song Gao

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioresources and bioprocessing, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
2.4field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Polyketides and alkaloids from the fungusFrontiers in pharmacology · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Jiacheng Guo *Jiangsu Key Laboratory of Marine Biological Resources and Environment, Jiangsu Key Laboratory of Marine Pharmaceutical Compound Screening, MNR Key Laboratory of Coastal Salt Marsh Ecosystems and Resources, School of Pharmacy, Co-Innovation Center of Jiangsu Marine Bio-Industry Technology, Jiangsu Ocean University, Lianyungang, 222005, China.
Jin Yang *Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, 130 Meilong Road, Shanghai, 200237, China.
Pei WangSchool of Food Science and Pharmaceutical Engineering, Nanjing Normal University, Nanjing, 210023, China.
Bo GuoJiangsu Key Laboratory of Marine Biological Resources and Environment, Jiangsu Key Laboratory of Marine Pharmaceutical Compound Screening, MNR Key Laboratory of Coastal Salt Marsh Ecosystems and Resources, School of Pharmacy, Co-Innovation Center of Jiangsu Marine Bio-Industry Technology, Jiangsu Ocean University, Lianyungang, 222005, China.
Huifang LiJiangsu Key Laboratory of Marine Biological Resources and Environment, Jiangsu Key Laboratory of Marine Pharmaceutical Compound Screening, MNR Key Laboratory of Coastal Salt Marsh Ecosystems and Resources, School of Pharmacy, Co-Innovation Center of Jiangsu Marine Bio-Industry Technology, Jiangsu Ocean University, Lianyungang, 222005, China.
Di ZhangJiangsu Key Laboratory of Marine Biological Resources and Environment, Jiangsu Key Laboratory of Marine Pharmaceutical Compound Screening, MNR Key Laboratory of Coastal Salt Marsh Ecosystems and Resources, School of Pharmacy, Co-Innovation Center of Jiangsu Marine Bio-Industry Technology, Jiangsu Ocean University, Lianyungang, 222005, China. dizhang@jou.edu.cn.ORCID http://orcid.org/0000-0001-7470-130X
Faliang AnKey Laboratory of Bioreactor Engineering, East China University of Science and Technology, 130 Meilong Road, Shanghai, 200237, China. flan2016@ecust.edu.cn.
Song GaoJiangsu Key Laboratory of Marine Biological Resources and Environment, Jiangsu Key Laboratory of Marine Pharmaceutical Compound Screening, MNR Key Laboratory of Coastal Salt Marsh Ecosystems and Resources, School of Pharmacy, Co-Innovation Center of Jiangsu Marine Bio-Industry Technology, Jiangsu Ocean University, Lianyungang, 222005, China. gaos@jou.edu.cn.
College of Marin · USEast China University of Science and Technology · CNNanjing Normal University · CN

Funding

he Program of Jiangsu Key Laboratory of Marine Pharmaceutical Compound Screening No. HY202001the Foundation from Jiangsu Province No. JSSCBS20211307the Natural Science Foundation of the Jiangsu Higher Education Institutions of China No. 22KJB170010the Program of MNR Key Laboratory of Coastal Salt Marsh Ecosystems and Resources No. KLCSMERMNR2021107the Scientific Research Foundation of Jiangsu Ocean University No. KQ20047
6 · The paper itself

Abstract

Vibrio species (Vibrio sp.) is a class of Gram-negative aquatic bacteria that causes vibriosis in aquaculture, which have resulted in big economic losses. Utilization of antibiotics against vibriosis has brought concerns on antibiotic resistance, and it is essential to explore potential antibiotic alternatives. In this study, seven compounds (compounds 1-7) were isolated from the Arctic endophytic fungus Penicillium sp. Z2230, among which compounds 3, 4, and 5 showed anti-Vibrio activity. The structures of the seven compounds were comprehensively elucidated, and the antibacterial mechanism of compounds 3, 4, and 5 was explored by molecular docking. The results suggested that the anti-Vibrio activity could come from inhibition of the bacterial peptide deformylase (PDF). This study discovered three Penicillium-derived compounds to be potential lead molecules for developing novel anti-Vibrio agents, and identified PDF as a promising antibacterial target. It also expanded the bioactive diversity of polar endophytic fungi by showing an example in which the secondary metabolites of a polar microbe were a good source of natural medicine.

Indexed as

Antibiotic resistanceAnti-vibriosisAquacultureArctic endophytic fungusNatural productsSecondary metabolites

Identifiers

PMID38647601
PMCPMC10992105
OpenAlexW4319030344

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.