Evidence map›Paper›PMID 38647526›Full record

ArticleAmerican journal of respiratory and critical care medicine2024

A Nanopore Sequencing-based Pharmacogenomic Panel to Personalize Tuberculosis Drug Dosing.

Renu Verma, Kesia Esther da Silva, Neesha Rockwood, Roeland E Wasmann, Nombuso Yende, Taeksun Song, Eugene Kim, Paolo Denti, Robert J Wilkinson, Jason R Andrews

Open access · hybridAbstract read
In one paragraph

Article in American journal of respiratory and critical care medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Observational
  9. Genetic and Genomic Approaches to the Study of Drug-Induced Liver Injury.Liver international : official journal of the International Association for the Study of the Liver · 2025
    Review
  10. Precision Medicine Strategies to Improve Isoniazid Therapy in Patients with Tuberculosis.European journal of drug metabolism and pharmacokinetics · 2024
    Review
  11. Another Step Closer to Genomic-informed Therapeutic Dosing for Tuberculosis Drugs.American journal of respiratory and critical care medicine · 2024
    Article
  12. A Nanopore Sequencing-based Pharmacogenomic Panel to Personalize Tuberculosis Drug Dosing.American journal of respiratory and critical care medicine · 2024
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 5 countries.

Renu VermaDivision of Infectious Diseases and Geographic Medicine, Stanford University School of Medicine, Stanford, California.ORCID 0000-0003-1277-8824
Kesia Esther da SilvaDivision of Infectious Diseases and Geographic Medicine, Stanford University School of Medicine, Stanford, California.
Neesha RockwoodWellcome Center for Infectious Diseases Research in Africa, Institute of Infectious Disease and Molecular Medicine and Department Medicine.
Roeland E WasmannDivision of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa.ORCID 0000-0002-5769-8150
Nombuso YendeDepartment of Pathology and Institute of Infectious Disease and Molecular Medicine, and.
Taeksun SongDepartment of Pathology and Institute of Infectious Disease and Molecular Medicine, and.ORCID 0000-0003-4478-4161
Eugene KimDivision of Infectious Diseases and Geographic Medicine, Stanford University School of Medicine, Stanford, California.ORCID 0000-0003-3409-4124
Paolo DentiDivision of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa.ORCID 0000-0001-7494-079X
Robert J WilkinsonWellcome Center for Infectious Diseases Research in Africa, Institute of Infectious Disease and Molecular Medicine and Department Medicine.ORCID 0000-0002-2753-1800
Jason R AndrewsDivision of Infectious Diseases and Geographic Medicine, Stanford University School of Medicine, Stanford, California.ORCID 0000-0002-5967-251X
Stanford University · USUniversity of Cape Town · ZAManipal Academy of Higher Education · INThe Francis Crick Institute · GBWellcome Centre for Infectious Diseases Research in Africa · ZA

Funding

Point-of-care pharmacogenomic testing to optimize isoniazid dosing for tuberculosis preventionR21AI172182 · NIAID · STANFORD UNIVERSITY · PI ANDREWS, JASON RANDOLPH, CRODA, JULIO HENRIQUE ROSA · 2022 to 2023
$422k
Cancer Research UK FC2112NIAID NIH HHS R21 AI172182NIH HHS R21 AI172182Wellcome Trust 203135Wellcome Trust CC2112
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Antitubercular AgentsNanopore SequencingPolymorphism, Single NucleotideTuberculosisAdultFemaleHumansIsoniazidMaleMiddle AgedPharmacogeneticsPharmacogenomic TestingPrecision MedicineRifampinSouth AfricaYoung AdultAntitubercular AgentsIsoniazidRifampinNanoporeNAT2pharmacogenomicstargeted sequencingtuberculosis

Identifiers

PMID38647526
PMCPMC11208962
OpenAlexW4392457914

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.