Evidence map›Paper›PMID 38647420›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2024

"Cicada Out of the Shell" Deep Penetration and Blockage of the HSP90 Pathway by ROS-Responsive Supramolecular Gels to Augment Trimodal Synergistic Therapy.

Fashun Li, Jianqin Yan, Chen Wei, Yi Zhao, Xiaowen Tang, Long Xu, Bin He, Yong Sun, Jing Chang, Yan Liang

Erratum issuedOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 12 citations in OpenAlex.

  1. Sulfur Vacancy-Enriched CuAngewandte Chemie (International ed. in English) · 2026
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Fashun LiDepartment of Pharmaceutics, School of Pharmacy, Qingdao University, Qingdao, 266073, China.
Jianqin YanDepartment of Pharmaceutics, School of Pharmacy, Qingdao University, Qingdao, 266073, China.
Chen WeiDepartment of Pharmacy, Qingdao Women and Children's Hospital, Qingdao, 266034, China.
Yi ZhaoDepartment of Recuperation Medicine, Qingdao Special Service Sanatorium of PLA Navy, Qingdao, 266071, China.
Xiaowen TangDepartment of Medicinal Chemistry, School of Pharmacy, Qingdao University, Qingdao, 266073, China.
Long XuSchool of Materials Science and Chemical Engineering, Ningbo University, Ningbo, 315211, China.
Bin HeNational Engineering Research Center for Biomaterials, Sichuan University, Chengdu, 610064, China.
Yong SunDepartment of Pharmaceutics, School of Pharmacy, Qingdao University, Qingdao, 266073, China.
Jing ChangCollege of Marine Life Science, Ocean University of China, Qingdao, 266003, China.
Yan LiangDepartment of Pharmaceutics, School of Pharmacy, Qingdao University, Qingdao, 266073, China.ORCID 0000-0003-1084-6117
Qingdao University · CNNingbo University · CNOcean University of China · CNSichuan University · CN

Funding

Key Project of Natural Science Foundation of Shandong Province ZR2020KE016key technology research and industrialization demonstration projects of Qingdao 22-3-3-hygg-25-hyPlan on Science and Technology for Youth Innovation of Universities in Shandong Province 2023KJ230Qingdao Science and Technology Demonstration and Guidance Project 21-1-4-rkjk-10-nshShandong Provincial Natural Science Foundation ZR2023ME059Shandong Provincial Natural Science Foundation ZR2023QH204
6 · The paper itself

Abstract

Deep penetration and downregulation of heat shock protein (HSP) expression in multimodal synergistic therapy are promising approaches for curing cancer in clinical trials. However, free small-molecule drugs and most drug vehicles have a low delivery efficiency deep into the tumor owing to poor drug penetration and hypoxic conditions at the tumor site. In this study, the objective is to use reactive oxygen species (ROS)-responsive supramolecular gels co-loaded with the photosensitizer Zn(II) phthalocyanine tetrasulfonic acid (ZnPCS

Indexed as

HSP90 Heat-Shock ProteinsPhotochemotherapyReactive Oxygen SpeciesAnimalsCell Line, TumorCombined Modality TherapyDisease Models, AnimalGelsHumansIndolesIsoindolesMicePhotosensitizing AgentsPhotothermal TherapyGelsHSP90 Heat-Shock ProteinsIndolesIsoindolesPhotosensitizing AgentsReactive Oxygen SpeciesHSP90multimodal synergistic therapypenetrationreactive oxygen species‐responsivesupramolecular gels

Identifiers

PMID38647420
PMCPMC11220648
OpenAlexW4394999543

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.