Evidence map›Paper›PMID 38647392›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2024

Antimicrobial and Antiviral Nanofibers Halt Co-Infection Spread via Nuclease-Mimicry and Photocatalysis.

Jieran Yao, Zhenhong Luo, Jiaying Lin, Na Meng, Jiangna Guo, Hui Xu, Rongwei Shi, Linhui Zhao, Jiateng Zhou, Feng Yan and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Jieran YaoDepartment of Critical Care Medicine, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
Zhenhong LuoCollege of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou, 215123, China.
Jiaying LinDepartment of Critical Care Medicine, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
Na MengDepartment of Critical Care Medicine, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
Jiangna GuoCollege of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou, 215123, China.
Hui XuCollege of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou, 215123, China.
Rongwei ShiSchool of Material and Chemical Engineering, Tongren University, Tongren, 554300, China.
Linhui ZhaoDepartment of Critical Care Medicine, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
Jiateng ZhouDepartment of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, China.
Feng YanCollege of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou, 215123, China.
Bin WangDepartment of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, China.
Hailei MaoDepartment of Critical Care Medicine, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.ORCID 0000-0003-2999-7142

Funding

Collaborative Innovation Center of Suzhou Nano ScienceNational Key R&D Program of China 2022YFC2703704National Natural Science Foundation of China 51973041National Natural Science Foundation of China 52173118Project Funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions
6 · The paper itself

Abstract

The escalating spread of drug-resistant bacteria and viruses is a grave concern for global health. Nucleic acids dominate the drug-resistance and transmission of pathogenic microbes. Here, imidazolium-type poly(ionic liquid)/porphyrin (PIL-P) based electrospun nanofibrous membrane and its cerium (IV) ion complex (PIL-P-Ce) are developed. The obtained PIL-P-Ce membrane exhibits high and stable efficiency in eradicating various microorganisms (bacteria, fungi, and viruses) and decomposing microbial antibiotic resistance genes and viral nucleic acids under light. The nuclease-mimetic and photocatalytic mechanisms of the PIL-P-Ce are elucidated. Co-infection wound models in mice with methicillin-resistant S. aureus and hepatitis B virus demonstrate that PIL-P-Ce integrate the triple effects of cationic polymer, photocatalysis, and nuclease-mimetic activities. As revealed by proteomic analysis, PIL-P-Ce shows minimal phototoxicity to normal tissues. Hence, PIL-P-Ce has potential as a "green" wound dressing to curb the spread of drug-resistant bacteria and viruses in clinical settings.

Indexed as

Anti-Infective AgentsAntiviral AgentsCoinfectionDisease Models, AnimalNanofibersAnimalsCatalysisIonic LiquidsMethicillin-Resistant Staphylococcus aureusMicePorphyrinsAnti-Infective AgentsAntiviral AgentsIonic LiquidsPorphyrinsantibiotic resistance genesantimicrobial and antiviral nanofibersartificial nucleasephotodynamic therapypoly(ionic liquid)viral nucleic acids

Identifiers

PMID38647392
PMCPMC11200001

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.