Evidence map›Paper›PMID 38647221›Full record

ArticleCerebral cortex (New York, N.Y. : 1991)2024

The Subcortical Atlas of the Marmoset ("SAM") monkey based on high-resolution MRI and histology.

Kadharbatcha S Saleem, Alexandru V Avram, Daniel Glen, Vincent Schram, Peter J Basser

Open access · bronzeAbstract read
In one paragraph

Article in Cerebral cortex (New York, N.Y. : 1991), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. A Community Standard Multispecies Cell Atlas of the Basal Ganglia.bioRxiv : the preprint server for biology · 2026
    Article
  2. Article
  3. Resting-state functional connectivity of the marmoset claustrum.Imaging neuroscience (Cambridge, Mass.) · 2025
    Article
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Kadharbatcha S SaleemSection on Quantitative Imaging and Tissue Sciences (SQITS), Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institute of Health (NIH), 13, South Drive, Bethesda, MD 20892, United States.ORCID 0000-0002-4450-9234
Alexandru V AvramSection on Quantitative Imaging and Tissue Sciences (SQITS), Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institute of Health (NIH), 13, South Drive, Bethesda, MD 20892, United States.ORCID 0000-0002-0295-601X
Daniel GlenScientific and Statistical Computing Core, National Institute of Mental Health (NIMH), NIH, 10 Center Drive, Bethesda, MD 20817, United States.
Vincent SchramMicroscopy and Imaging Core (MIC), Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), NIH, 35 Convent Drive, Bethesda, MD 20892, United States.
Peter J BasserSection on Quantitative Imaging and Tissue Sciences (SQITS), Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institute of Health (NIH), 13, South Drive, Bethesda, MD 20892, United States.
Eunice Kennedy Shriver National Institute of Child Health and Human Development · USHenry M. Jackson Foundation · USNational Institute of Mental Health · US

Funding

CONNECTOME 2.0: DEVELOPING THE NEXT GENERATION HUMAN MRI SCANNER FOR BRIDGING STUDIES OF THE MICRO-, MESO- AND MACRO-CONNECTOMEU01EB026996 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI BASSER, PETER J., HUANG, SUSIE YI · 2018 to 2022
$14.2M
CNRM Neuroradiology/Neuropathology Correlation/Integration Core 309698-4.01-65310Intramural Research Program of the Eunice Kennedy Shriver National Institute of Child Health and Human DevelopmentIntramural Research Program of the National Institute of Neurological Disorders and StrokeNIBIB NIH HHS U01 EB026996NIH BRAIN 1U01EB026996-01
6 · The paper itself

Abstract

A comprehensive three-dimensional digital brain atlas of cortical and subcortical regions based on MRI and histology has a broad array of applications in anatomical, functional, and clinical studies. We first generated a Subcortical Atlas of the Marmoset, called the "SAM," from 251 delineated subcortical regions (e.g. thalamic subregions, etc.) derived from high-resolution Mean Apparent Propagator-MRI, T2W, and magnetization transfer ratio images ex vivo. We then confirmed the location and borders of these segmented regions in the MRI data using matched histological sections with multiple stains obtained from the same specimen. Finally, we estimated and confirmed the atlas-based areal boundaries of subcortical regions by registering this ex vivo atlas template to in vivo T1- or T2W MRI datasets of different age groups (single vs. multisubject population-based marmoset control adults) using a novel pipeline developed within Analysis of Functional NeuroImages software. Tracing and validating these important deep brain structures in 3D will improve neurosurgical planning, anatomical tract tracer injections, navigation of deep brain stimulation probes, functional MRI and brain connectivity studies, and our understanding of brain structure-function relationships. This new ex vivo template and atlas are available as volumes in standard NIFTI and GIFTI file formats and are intended for use as a reference standard for marmoset brain research.

Indexed as

Atlases as TopicBrainCallithrixMagnetic Resonance ImagingAnimalsFemaleImage Processing, Computer-AssistedImaging, Three-DimensionalMalehistologyMAP-MRImarmoset monkeySAMsubcortical atlas

Identifiers

PMID38647221
PMCPMC11494440
OpenAlexW4394992379

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.