Evidence map›Paper›PMID 38647069›Full record

ArticleNucleic acids research2024

SifiNet: a robust and accurate method to identify feature gene sets and annotate cells.

Qi Gao, Zhicheng Ji, Liuyang Wang, Kouros Owzar, Qi-Jing Li, Cliburn Chan, Jichun Xie

Abstract read
In one paragraph

Article in Nucleic acids research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Qi GaoDepartment of Biostatistics and Bioinformatics, Duke University, USA.
Zhicheng JiDepartment of Biostatistics and Bioinformatics, Duke University, USA.ORCID 0000-0002-9457-4704
Liuyang WangDepartment of Molecular Genetics and Microbiology, Duke University, USA.
Kouros OwzarDepartment of Biostatistics and Bioinformatics, Duke University, USA.ORCID 0000-0002-3340-1287
Qi-Jing LiInstitute of Molecular and Cell Biology, Agency for Science, Technology and Research, Singapore.
Cliburn ChanDepartment of Biostatistics and Bioinformatics, Duke University, USA.
Jichun XieDepartment of Biostatistics and Bioinformatics, Duke University, USA.ORCID 0000-0001-5905-6728

Funding

The Duke Senescent Cell Evaluations in Normal Tissues (SCENT) Mapping CenterU54AG075936 · NIA · DUKE UNIVERSITY · PI NIXON, ANDREW B. · 2021 to 2025
$12.7M
New computational methods to dynamically pinpointing the subregions carrying disease-associated rare variantsR01HG012555 · NHGRI · DUKE UNIVERSITY · PI XIE, JICHUN · 2022 to 2025
$1.6M
Area A: Development of genetically tractable, driver gene-syngeneic brain tumor models for pre-clinical adoptive TCR-T therapyR33CA225328 · NCI · DUKE UNIVERSITY · PI ASHLEY, DAVID M., LI, QIJING · 2017 to 2017
$1.5M
Duke University R33 CA225328National Institute of AgingNCI NIH HHS R33 CA225328NHGRI NIH HHS R01 HG012555NIA NIH HHS U54 AG075936NIH HHS U54AG075936
6 · The paper itself

Abstract

SifiNet is a robust and accurate computational pipeline for identifying distinct gene sets, extracting and annotating cellular subpopulations, and elucidating intrinsic relationships among these subpopulations. Uniquely, SifiNet bypasses the cell clustering stage, commonly integrated into other cellular annotation pipelines, thereby circumventing potential inaccuracies in clustering that may compromise subsequent analyses. Consequently, SifiNet has demonstrated superior performance in multiple experimental datasets compared with other state-of-the-art methods. SifiNet can analyze both single-cell RNA and ATAC sequencing data, thereby rendering comprehensive multi-omic cellular profiles. It is conveniently available as an open-source R package.

Indexed as

Single-Cell AnalysisSoftwareAlgorithmsChromatin Immunoprecipitation SequencingCluster AnalysisComputational BiologyGene Expression ProfilingHumansMolecular Sequence AnnotationSequence Analysis, RNA

Identifiers

PMID38647069
PMCPMC11109959

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.