ArticleHuman brain mapping2024
Evoked oscillatory cortical activity during acute pain: Probing brain in pain by transcranial magnetic stimulation combined with electroencephalogram.
Article in Human brain mapping, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 18 citations in OpenAlex.
- Modulation of evoked alpha oscillatory activity in the frontocentral region during analgesia by non-invasive brain stimulation.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026Trial
- Motor cortex repetitive transcranial magnetic stimulation in fibromyalgia: a multicentre randomised controlled trial.British journal of anaesthesia · 2025Trial
- Toward a Predictive Coding Account of Hypnotic Hypoalgesia: Integrating EEG Oscillations and Somatosensory Evoked Responses.Brain sciences · 2026Review
- Pain Is in the Timing: The Emerging Importance of Phase-Based EEG Connectivity.European journal of pain (London, England) · 2026Article
- Breathing-Controlled Electrical Stimulation (BreEStim) Selectively Modulates Affective and Cognitive Components of Pain-An EEG Study.Bioengineering (Basel, Switzerland) · 2026Article
- Alpha oscillations in pain neuromodulation: From resting rhythms to reactive networks.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026Article
- Clinical utility and prospective of TMS-EEG: Updated review from an international expert group.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2026Review
- A bioelectromagnetic hypothesis of chronic primary pain: from thalamocortical dysrhythmia to the consciousness-brain interface.Frontiers in pain research (Lausanne, Switzerland) · 2026Article
- Bridging the Gap in Pain Measurement with a Brain-Based Index.International journal of environmental research and public health · 2025Article
- The cortical mechanisms underlying the analgesic effects of repetitive transcranial magnetic stimulation: protocol for a systematic review and meta-analysis.Systematic reviews · 2025Article
- Differential Effects of Repetitive Transcranial Magnetic Stimulation on Mood and Pain Symptoms in People With Chronic Pain and Major Depressive Disorders-A Review.European journal of pain (London, England) · 2025Review
- Preemptive transcranial direct current stimulation mitigates susceptibility to persistent pain.Communications biology · 2025Article
- Review
- Evoked oscillatory cortical activity during acute pain: Probing brain in pain by transcranial magnetic stimulation combined with electroencephalogram.Human brain mapping · 2024Article
- Extracting reproducible components from electroencephalographic responses to transcranial magnetic stimulation with group task-related component analysis.Imaging neuroscience (Cambridge, Mass.)Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 3 countries.
Funding
Abstract
Temporal dynamics of local cortical rhythms during acute pain remain largely unknown. The current study used a novel approach based on transcranial magnetic stimulation combined with electroencephalogram (TMS-EEG) to investigate evoked-oscillatory cortical activity during acute pain. Motor (M1) and dorsolateral prefrontal cortex (DLPFC) were probed by TMS, respectively, to record oscillatory power (event-related spectral perturbation and relative spectral power) and phase synchronization (inter-trial coherence) by 63 EEG channels during experimentally induced acute heat pain in 24 healthy participants. TMS-EEG was recorded before, during, and after noxious heat (acute pain condition) and non-noxious warm (Control condition), delivered in a randomized sequence. The main frequency bands (α, β1, and β2) of TMS-evoked potentials after M1 and DLPFC stimulation were recorded close to the TMS coil and remotely. Cold and heat pain thresholds were measured before TMS-EEG. Over M1, acute pain decreased α-band oscillatory power locally and α-band phase synchronization remotely in parietal-occipital clusters compared with non-noxious warm (all p < .05). The remote (parietal-occipital) decrease in α-band phase synchronization during acute pain correlated with the cold (p = .001) and heat pain thresholds (p = .023) and to local (M1) α-band oscillatory power decrease (p = .024). Over DLPFC, acute pain only decreased β1-band power locally compared with non-noxious warm (p = .015). Thus, evoked-oscillatory cortical activity to M1 stimulation is reduced by acute pain in central and parietal-occipital regions and correlated with pain sensitivity, in contrast to DLPFC, which had only local effects. This finding expands the significance of α and β band oscillations and may have relevance for pain therapies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.