Evidence map›Paper›PMID 38646975›Full record

ArticleMicrobial biotechnology2024

Identification of a potent PCNA-p15-interaction inhibitor by autodisplay-based peptide library screening.

Sarah Hardebeck, Natalie Jácobo Goebbels, Caroline Michalski, Sebastian Schreiber, Joachim Jose

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Microbial biotechnology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.4field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Microbes Saving Lives and Reducing Suffering.Microbial biotechnology · 2025
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Sarah HardebeckUniversity of Münster, Institute of Pharmaceutical and Medicinal Chemistry, Münster, Germany.
Natalie Jácobo GoebbelsUniversity of Münster, Institute of Pharmaceutical and Medicinal Chemistry, Münster, Germany.
Caroline MichalskiUniversity of Münster, Institute of Pharmaceutical and Medicinal Chemistry, Münster, Germany.
Sebastian SchreiberUniversity of Münster, Institute of Pharmaceutical and Medicinal Chemistry, Münster, Germany.ORCID 0009-0000-0516-2744
Joachim JoseUniversity of Münster, Institute of Pharmaceutical and Medicinal Chemistry, Münster, Germany.ORCID 0000-0002-0666-2676
University of Münster · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Proliferating cell nuclear antigen (PCNA) is an essential factor for DNA metabolism. The influence of PCNA on DNA replication and repair, combined with the high expression rate of PCNA in various tumours renders PCNA a promising target for cancer therapy. In this context, an autodisplay-based screening method was developed to identify peptidic PCNA interaction inhibitors. A 12-mer randomized peptide library consisting of 2.54 × 10

Indexed as

Escherichia coliPeptide LibraryProliferating Cell Nuclear AntigenProtein BindingCell Surface Display TechniquesDrug Evaluation, PreclinicalFlow CytometryHumansPeptidesPCNA protein, humanPeptide LibraryPeptidesProliferating Cell Nuclear Antigen

Identifiers

PMID38646975
PMCPMC11033925
OpenAlexW4395008448

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.