Evidence map›Paper›PMID 38646958›Full record

ArticleMultiple sclerosis (Houndmills, Basingstoke, England)2024

Optic chiasm involvement in multiple sclerosis, aquaporin-4 antibody-positive neuromyelitis optica spectrum disorder and myelin oligodendrocyte glycoprotein-associated disease.

Alessia Bianchi, Rosa Cortese, Ferran Prados, Carmen Tur, Baris Kanber, Marios C Yiannakas, Rebecca Samson, Floriana De Angelis, Lise Magnollay, Anu Jacob and 7 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Multiple sclerosis (Houndmills, Basingstoke, England), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
2.1field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 5 institutions in 4 countries.

Alessia BianchiQueen Square MS Centre, Department of Neuroinflammation, UCL Queen Square Institute of Neurology, Faculty of Brain Sciences, University College London, London, UK.
Rosa CorteseQueen Square MS Centre, Department of Neuroinflammation, UCL Queen Square Institute of Neurology, Faculty of Brain Sciences, University College London, London, UK.ORCID 0000-0002-9803-7914
Ferran PradosQueen Square MS Centre, Department of Neuroinflammation, UCL Queen Square Institute of Neurology, Faculty of Brain Sciences, University College London, London, UK.
Carmen TurQueen Square MS Centre, Department of Neuroinflammation, UCL Queen Square Institute of Neurology, Faculty of Brain Sciences, University College London, London, UK.ORCID 0000-0003-1849-3184
Baris KanberQueen Square MS Centre, Department of Neuroinflammation, UCL Queen Square Institute of Neurology, Faculty of Brain Sciences, University College London, London, UK.
Marios C YiannakasQueen Square MS Centre, Department of Neuroinflammation, UCL Queen Square Institute of Neurology, Faculty of Brain Sciences, University College London, London, UK.
Rebecca SamsonQueen Square MS Centre, Department of Neuroinflammation, UCL Queen Square Institute of Neurology, Faculty of Brain Sciences, University College London, London, UK.ORCID 0000-0002-0197-702X
Floriana De AngelisQueen Square MS Centre, Department of Neuroinflammation, UCL Queen Square Institute of Neurology, Faculty of Brain Sciences, University College London, London, UK.
Lise MagnollayQueen Square MS Centre, Department of Neuroinflammation, UCL Queen Square Institute of Neurology, Faculty of Brain Sciences, University College London, London, UK.
Anu JacobDepartment of Neurology, The Walton Centre NHS Foundation Trust, Liverpool, UK.
Wallace BrownleeQueen Square MS Centre, Department of Neuroinflammation, UCL Queen Square Institute of Neurology, Faculty of Brain Sciences, University College London, London, UK.
Anand TripQueen Square MS Centre, Department of Neuroinflammation, UCL Queen Square Institute of Neurology, Faculty of Brain Sciences, University College London, London, UK.
Richard NicholasDivision of Brain Sciences, Department of Medicine, Imperial College London, London, UK.ORCID 0000-0003-0414-1225
Yael HacohenQueen Square MS Centre, Department of Neuroinflammation, UCL Queen Square Institute of Neurology, Faculty of Brain Sciences, University College London, London, UK.
Frederik BarkhofQueen Square MS Centre, Department of Neuroinflammation, UCL Queen Square Institute of Neurology, Faculty of Brain Sciences, University College London, London, UK.
Olga CiccarelliQueen Square MS Centre, Department of Neuroinflammation, UCL Queen Square Institute of Neurology, Faculty of Brain Sciences, University College London, London, UK.
Ahmed T ToosyQueen Square MS Centre, Department of Neuroinflammation, UCL Queen Square Institute of Neurology, Faculty of Brain Sciences, University College London, London, UK.ORCID 0000-0002-4441-3750
Queen Mary University of London · GBUniversity of Siena · ITImperial College London · GBUniversitat Oberta de Catalunya · ESUniversity of Liverpool · GB

Funding

Medical Research Council MR/S026088/1
6 · The paper itself

Abstract

backgroundOptic neuritis (ON) is a common feature of inflammatory demyelinating diseases (IDDs) such as multiple sclerosis (MS), aquaporin 4-antibody neuromyelitis optica spectrum disorder (AQP4 + NMOSD) and myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD). However, the involvement of the optic chiasm (OC) in IDD has not been fully investigated.

aimsTo examine OC differences in non-acute IDD patients with (ON+) and without ON (ON-) using magnetisation transfer ratio (MTR), to compare differences between MS, AQP4 + NMOSD and MOGAD and understand their associations with other neuro-ophthalmological markers.

methodsTwenty-eight relapsing-remitting multiple sclerosis (RRMS), 24 AQP4 + NMOSD, 28 MOGAD patients and 32 healthy controls (HCs) underwent clinical evaluation, MRI and optical coherence tomography (OCT) scan. Multivariable linear regression models were applied.

resultsON + IDD patients showed lower OC MTR than HCs (28.87 ± 4.58 vs 31.65 ± 4.93;

conclusionOC microstructural damage indicates prior ON in IDD and is linked to reduced vision and thinner pRNFL.

Indexed as

Aquaporin 4AutoantibodiesMultiple Sclerosis, Relapsing-RemittingMyelin-Oligodendrocyte GlycoproteinNeuromyelitis OpticaOptic ChiasmTomography, Optical CoherenceAdultFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedOptic NeuritisYoung AdultAQP4 protein, humanAquaporin 4AutoantibodiesMyelin-Oligodendrocyte Glycoproteinaquaporin4-antibody neuromyelitis optica spectrum disordermagnetisation transfer ratiomultiple sclerosismyelin oligodendrocyte glycoprotein antibody–associated diseaseOptic chiasmoptic neuritis

Identifiers

PMID38646958
PMCPMC11103893
OpenAlexW4395002342

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.