ArticleCirculation. Arrhythmia and electrophysiology2024
Mortality, Hospitalization, and Cardiac Interventions in Patients With Atrial Fibrillation Aged <65 Years.
Article in Circulation. Arrhythmia and electrophysiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Bidirectional association between COPD and AF: a systematic review and meta-analysis.Frontiers in cardiovascular medicine · 2026Pooled it
- Accumulation of chronic conditions in patients aged <65 years diagnosed with atrial fibrillation.Heart rhythm · 2026Article
- Comprehensive Analysis of Atrial Fibrillation/Atrial Flutter Burden in the United States and the European Union: A Comparison and Assessment of Trends and Risk Factors.Journal of cardiovascular development and disease · 2026Article
- Long-Term Outcomes With Class 1C Antiarrhythmic Drug Use in Atrial Fibrillation.Journal of the American Heart Association · 2026Observational
- Mortality, Hospitalization, and Cardiac Interventions Among Patients With Mitral Valve Prolapse <65 Years of Age.Journal of the American Heart Association · 2026Article
- The characteristics and clinical outcomes of atrial fibrillation patient in middle income country of Indonesia.Frontiers in cardiovascular medicine · 2026Article
- Clinical complexity in patients with atrial fibrillation: exploring differential risk profiles from European and Asian cohorts.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2025Article
- Trends in atrial fibrillation-related mortality among adults under 65 years in the USA.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2025Article
- Predictive value of the systemic immune inflammation index in recurrence of atrial fibrillation after radiofrequency catheter ablation.World journal of cardiology · 2025Article
- Multimorbidity in patients with atrial fibrillation and community controls: A population-based study.Journal of multimorbidity and comorbidityArticle
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Authors and funding
12 authors.
Funding
Abstract
backgroundThe risk factor (RF) burden, clinical course, and long-term outcome among patients with atrial fibrillation (AF) aged <65 years is unclear.
methodsAdult (n=67 221; mean age, 72.4±12.3 years; and 45% women) patients with AF evaluated at the University of Pittsburgh Medical Center between January 2010 and December 2019 were studied. Hospital system-wide electronic health records and administrative data were utilized to ascertain RFs, comorbidities, and subsequent hospitalization and cardiac interventions. The association of AF with all-cause mortality among those aged <65 years was analyzed using an internal contemporary cohort of patients without AF (n=918 073).
resultsNearly one-quarter (n=17 335) of the cohort was aged <65 years (32% women) with considerable cardiovascular RFs (current smoker, 16%; mean body mass index, 33.0±8.3; hypertension, 55%; diabetes, 21%; heart failure, 20%; coronary artery disease, 19%; and prior ischemic stroke, 6%) and comorbidity burden (chronic obstructive pulmonary disease, 11%; obstructive sleep apnea, 18%; and chronic kidney disease, 1.3%). Over mean follow-up of >5 years, 2084 (6.7%, <50 years; 13%, 50-65 years) patients died. The proportion of patients with >1 hospitalization for myocardial infarction, heart failure, and stroke was 1.3%, 4.8%, and 1.1% for those aged <50 years and 2.2%, 7.4%, and 1.1% for the 50- to 65-year subgroup, respectively. Multiple cardiac and noncardiac RFs were associated with increased mortality in younger patients with AF with heart failure and hypertension demonstrating significant age-related interaction (
conclusionsPatients with AF aged <65 years have significant comorbidity burden and considerable long-term mortality. They are also at a significantly increased risk of hospitalization for heart failure, stroke, and myocardial infarction. These patients warrant an aggressive focus on RF and comorbidity evaluation and management.
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