Evidence map›Paper›PMID 38646599›Full record

ArticleIDCases2024

Malignant syphilis requiring differentiation from Kaposi's sarcoma.

Mieko Tokano, Norihito Tarumoto, Kazuo Imai, Hiroshi Yamaguchi, Masaaki Takeji, Fumito Inayoshi, Keita Okamoto, Nobuhito Okumura, Shigefumi Maesaki

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in IDCases, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 citations in OpenAlex.

  1. Epidemiology and treatment in patients with HIV in a secondary-level hospital in Mexico.Revista peruana de medicina experimental y salud publica · 2025
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Mieko TokanoDepartment of Infectious Disease and Infection Control, Saitama Medical University, 38 Morohongo, Moroyama, Saitama 350-0495, Japan.
Norihito TarumotoDepartment of Infectious Disease and Infection Control, Saitama Medical University, 38 Morohongo, Moroyama, Saitama 350-0495, Japan.
Kazuo ImaiDepartment of Infectious Disease and Infection Control, Saitama Medical University, 38 Morohongo, Moroyama, Saitama 350-0495, Japan.
Hiroshi YamaguchiDepartment of Pathology, Faculty of Medicine, Saitama Medical University, 38 Morohongo, Moroyama, Saitama 350-0495, Japan.
Masaaki TakejiDepartment of Dermatology, Saitama Medical University, 38 Morohongo, Moroyama, Saitama 350-0495, Japan.
Fumito InayoshiDepartment of Rheumatology and Applied Immunology, Saitama Medical University, 38 Morohongo, Moroyama, Saitama 350-0495, Japan.
Keita OkamotoDepartment of Rheumatology and Applied Immunology, Saitama Medical University, 38 Morohongo, Moroyama, Saitama 350-0495, Japan.
Nobuhito OkumuraDepartment of Rheumatology and Applied Immunology, Saitama Medical University, 38 Morohongo, Moroyama, Saitama 350-0495, Japan.
Shigefumi MaesakiDepartment of Infectious Disease and Infection Control, Saitama Medical University, 38 Morohongo, Moroyama, Saitama 350-0495, Japan.
Saitama Medical University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Malignant syphilis (MS) is a rare variant of secondary syphilis. Also known as rupioid syphilis, MS is characterized by the presence of multiple papules, papulopustules, black lamellate crust that may resemble an oyster shell, or nodules with ulceration lacking central clearing. MS is often associated with immunodeficiency and frequently co-occurs with HIV infection. We here report a case of MS in a patient with HIV infection. HIV infection can cause atypical clinical symptoms of syphilis. In this case, unlike previous cases, cutaneous lesions of MS were limited to the face, making the diagnosis challenging based on clinical findings alone. However, his laboratory findings, appearance of the Jarisch-Herxheimer reaction, and a dramatic response to antibiotic therapy are characteristic of MS, making the diagnosis even more certain. Our case suggests the importance of physicians considering the possibility of MS when observing black-crusted lesions.

Indexed as

Atypical cutaneous lesionsHIV infectionKaposi's sarcomaMalignant syphilisRupioid syphilisSecondary syphilis

Identifiers

PMID38646599
PMCPMC11031774
OpenAlexW4394850633

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.