Evidence map›Paper›PMID 38646510›Full record

ArticleFrontiers in pediatrics2024

Navigating cholestasis: identifying inborn errors of bile acid metabolism for precision diagnosis.

Hiroshi Nittono, Mitsuyoshi Suzuki, Hiromi Suzuki, Satoru Sugimoto, Jun Mori, Rieko Sakamoto, Yugo Takaki, Hisamitsu Hayashi, Hajime Takei, Akihiko Kimura

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in pediatrics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
2.3field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Autosomal recessiveMolecular genetics and metabolism reports · 2026
    Article
  2. Development of biomaterials for bone tissue engineering based on bile acids.Journal of materials science. Materials in medicine · 2025
    Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 9 institutions in 1 country.

Hiroshi NittonoDivision of Analysis Technology, Junshin Clinic Bile Acid Institute, Tokyo, Japan.
Mitsuyoshi SuzukiDepartment of Pediatrics, Juntendo University Faculty of Medicine, Tokyo, Japan.
Hiromi SuzukiDivision of Analysis Technology, Junshin Clinic Bile Acid Institute, Tokyo, Japan.
Satoru SugimotoDepartment of Pediatrics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Jun MoriDivision of Pediatric Endocrinology and Metabolism, Children's Medical Center, Osaka City General Hospital, Osaka, Japan.
Rieko SakamotoDepartment of Pediatrics and Pediatric Surgery, Juzen Hospital, Kumamoto, Japan.
Yugo TakakiDepartment of Pediatric Gastroenterology and Hepatology, Japanese Red Cross Kumamoto Hospital, Kumamoto, Japan.
Hisamitsu HayashiLaboratory of Molecular Pharmacokinetics, Graduate School of Pharmaceutical Science, The University of Tokyo, Tokyo, Japan.
Hajime TakeiDivision of Analysis Technology, Junshin Clinic Bile Acid Institute, Tokyo, Japan.
Akihiko KimuraDepartment of Pediatrics, Kumamoto-Ashikita Medical Center for the Severity Disabled, Kumamoto, Japan.
Tokyo Junshin University · JPJapanese Red Cross Kumamoto Hospital · JPJuntendo University · JPKumamoto Medical Center · JPKumamoto Orthopedic Surgery Hospital · JPKyoto Prefectural University of Medicine · JPOsaka City General Hospital · JPShowa University · JPThe University of Tokyo · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Inborn errors of bile acid metabolism (IEBAM) cause cholestasis during the neonatal period, and 8 types of IEBAM have been reported to date. IEBAM accounts for approximately 2% of cases of cholestasis of unknown cause. As only 10 patients have been identified in Japan, IEBAM presents diagnostic challenges due to the similarity of clinical symptoms with biliary atresia, thus necessitating precise differentiation to avoid unnecessary invasive procedures. Laboratory tests in IEBAM are characterized by normal

Indexed as

biliary atresiainborn errors of bile acid metabolismopen cholangiographyserum total bile acidγ-glutamyltransferase

Identifiers

PMID38646510
PMCPMC11026588
OpenAlexW4393984846

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.