Evidence map›Paper›PMID 38646175›Full record

ReviewiScience2024

Inhibitors to degraders: Changing paradigm in drug discovery.

V Haridas, Souvik Dutta, Akshay Munjal, Shailja Singh

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in iScience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

V HaridasDepartment of Chemistry, Indian Institute of Technology Delhi, Hauz Khas, New Delhi 110016, India.
Souvik DuttaDepartment of Chemistry, Indian Institute of Technology Delhi, Hauz Khas, New Delhi 110016, India.
Akshay MunjalSpecial Centre for Molecular Medicine, Jawaharlal Nehru University, New Delhi, New Delhi 110067, India.
Shailja SinghSpecial Centre for Molecular Medicine, Jawaharlal Nehru University, New Delhi, New Delhi 110067, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The chemical understanding of biological processes provides not only a deeper insight but also a solution to abnormal biological functioning. Protein degradation, a natural biological process for debris removal in the cell, has been studied for years. The recent finding that natural degradation pathways can be utilized for therapeutic purposes is a paradigm shift in the drug discovery approach. Methods such as Proteolysis Targeting Chimera (PROTAC), lysosomal targeting chimera, hydrophobic tagging, AUtophagy TArgeting Chimera, AUTOphagy TArgeting Chimera and several other variants of these methods have made a considerable impact on the way of drug design. Few selected examples testify that a huge wave of change is on the way. The drug design based on the targeted protein degradation is a powerful tool in our arsenal. More molecules will be invented that will uncover the hidden secrets of biological functioning and provide enduring solutions to several unmet medical needs.

Indexed as

BiochemistryBiological sciencesCell biologyProtein

Identifiers

PMID38646175
PMCPMC11031827

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.