Evidence map›Paper›PMID 38646069›Full record

ArticleDevelopmental psychobiology2024

Developmental Windows for Effects of Choline and Folate on Excitatory and Inhibitory Neurotransmission During Human Gestation.

Sharon K Hunter, M Camille Hoffman, Angelo D'Alessandro, Robert Freedman

Open access · greenAbstract read
In one paragraph

Article in Developmental psychobiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.4field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Sharon K HunterDepartment of Psychiatry, University of Colorado School of Medicine.ORCID 0000-0003-4136-1673
M Camille HoffmanDivision of Maternal and Fetal Medicine, Department of Obstetrics and Gynecology, University of Colorado School of Medicine.ORCID 0000-0003-3116-4502
Angelo D'AlessandroDepartment of Biochemistry and Molecular Genetics, University of Colorado School of Medicine.ORCID 0000-0002-2258-6490
Robert FreedmanDepartment Pharmacology, University of Colorado School of Medicine.ORCID 0000-0002-2181-2898
University of Colorado Denver · US

Funding

Colorado Clinical and Translational Sciences InstituteUL1TR001082 · NCATS · UNIVERSITY OF COLORADO DENVER · PI SOKOL, RONALD J. · 2013 to 2017
$48.0M
Colorado Clinical and Translational Sciences Institute (CCTSI)UM1TR004399 · NCATS · UNIVERSITY OF COLORADO DENVER · PI JANINE A HIGGINS, RONALD J. SOKOL · 2023 to 2026
$30.7M
COLORADO WRHR CAREER DEVELOPMENT CENTERK12HD001271 · NICHD · UNIVERSITY OF COLORADO DENVER · PI Saketh R Guntupalli · 1999 to 2026
$8.9M
NCATS NIH HHS UL1 TR001082NCATS NIH HHS UM1 TR004399NICHD NIH HHS K12 HD001271
6 · The paper itself

Abstract

Choline and folate are critical nutrients for fetal brain development, but the timing of their influence during gestation has not been previously characterized. At different periods during gestation, choline stimulation of α7-nicotinic receptors facilitates conversion of γ-aminobutyric acid (GABA) receptors from excitatory to inhibitory and recruitment of GluR1-R2 receptors for faster excitatory responses to glutamate. The outcome of the fetal development of inhibition and excitation was assessed in 159 newborns by P50 cerebral auditory-evoked responses. Paired stimuli, S1, S2, were presented 500 msec apart. Higher P50 amplitude in response to S1 (P50

Indexed as

CholineEvoked Potentials, AuditoryFolic AcidAdultChild DevelopmentChild, PreschoolFemaleFetal DevelopmentGestational AgeHumansInfant, NewbornMalePregnancySynaptic TransmissionCholineFolic AcidAttentionBrainCholineEvoked Potentials AuditoryExcitationFetal DevelopmentHippocampusHumanInhibitionPhosphatidylcholinePregnancy

Identifiers

PMID38646069
PMCPMC11031125
OpenAlexW4390698302

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.