Evidence map›Paper›PMID 38645773›Full record

ArticleFrontiers in radiology2024

Fusion of biomedical imaging studies for increased sample size and diversity: a case study of brain MRI.

Matias Aiskovich, Eduardo Castro, Jenna M Reinen, Shreyas Fadnavis, Anushree Mehta, Hongyang Li, Amit Dhurandhar, Guillermo A Cecchi, Pablo Polosecki

Abstract read
In one paragraph

Article in Frontiers in radiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Alzheimer's Disease Brain Phenotypes are Age-dependent.bioRxiv : the preprint server for biology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Matias AiskovichSilverGate Team, IBM Argentina, Buenos Aires, Argentina.
Eduardo CastroIBM T. J. Watson Research Center, Yorktown Heights, New York, NY, United States.
Jenna M ReinenIBM T. J. Watson Research Center, Yorktown Heights, New York, NY, United States.
Shreyas FadnavisIBM T. J. Watson Research Center, Yorktown Heights, New York, NY, United States.
Anushree MehtaIBM T. J. Watson Research Center, Yorktown Heights, New York, NY, United States.
Hongyang LiIBM T. J. Watson Research Center, Yorktown Heights, New York, NY, United States.
Amit DhurandharIBM T. J. Watson Research Center, Yorktown Heights, New York, NY, United States.
Guillermo A CecchiIBM T. J. Watson Research Center, Yorktown Heights, New York, NY, United States.
Pablo PoloseckiIBM T. J. Watson Research Center, Yorktown Heights, New York, NY, United States.

Funding

Alzheimer's Disease Neuroimaging Initiative - SupplementU01AG024904 · NIA · NORTHERN CALIFORNIA INSTITUTE RES &EDUC · PI WEINER, MICHAEL W · 2004 to 2015
$121.0M
Smartphone-Based "Burst" Cognitive AssessmentsP01AG003991 · NIA · WASHINGTON UNIVERSITY · PI Tammie Lee Smith Benzinger · 1985 to 2026
$69.5M
The natural history of AB accumulation in preclinical ADP01AG026276 · NIA · WASHINGTON UNIVERSITY · PI SCHINDLER, SUZANNE ELIZABETH · 2005 to 2025
$49.5M
NEUROBIOLOGICAL PREDICTORS OF HUNTINGTON'S DISEASER01NS040068 · NINDS · UNIVERSITY OF IOWA · PI PAULSEN, JANE S · 2001 to 2013
$48.5M
Research Education ComponentP30AG066444 · NIA · WASHINGTON UNIVERSITY · PI DAVID M. HOLTZMAN · 2020 to 2026
$28.7M
NIA NIH HHS P01 AG003991NIA NIH HHS P01 AG026276NIA NIH HHS P30 AG066444NIA NIH HHS U01 AG024904NINDS NIH HHS R01 NS040068
6 · The paper itself

Abstract

Data collection, curation, and cleaning constitute a crucial phase in Machine Learning (ML) projects. In biomedical ML, it is often desirable to leverage multiple datasets to increase sample size and diversity, but this poses unique challenges, which arise from heterogeneity in study design, data descriptors, file system organization, and metadata. In this study, we present an approach to the integration of multiple brain MRI datasets with a focus on homogenization of their organization and preprocessing for ML. We use our own fusion example (approximately 84,000 images from 54,000 subjects, 12 studies, and 88 individual scanners) to illustrate and discuss the issues faced by study fusion efforts, and we examine key decisions necessary during dataset homogenization, presenting in detail a database structure flexible enough to accommodate multiple observational MRI datasets. We believe our approach can provide a basis for future similarly-minded biomedical ML projects.

Indexed as

biomedical machine learningbrain MRIdata preparationdata scarcitydataset fusion

Identifiers

PMID38645773
PMCPMC11026619

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.