Evidence map›Paper›PMID 38645611›Full record

ArticleMRS bulletin2024

Flexible multifunctional titania nanotube array platform for biological interfacing.

Hoda Amani Hamedani, Thomas Stegall, Yi Yang, Haochen Wang, Ashwin Menon, Anubhuti Bhalotia, Efstathios Karathanasis, Jeffrey R Capadona, Allison Hess-Dunning

Open access · hybridAbstract read
In one paragraph

Article in MRS bulletin, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Hoda Amani HamedaniAdvanced Platform Technology Center, Louis Stokes Cleveland Veterans Affairs Medical Center, Cleveland, USA.ORCID 0000-0001-7129-5019
Thomas StegallAdvanced Platform Technology Center, Louis Stokes Cleveland Veterans Affairs Medical Center, Cleveland, USA.
Yi YangDepartment of Electrical, Computer, and Systems Engineering, Case Western Reserve University, Cleveland, USA.
Haochen WangDepartment of Electrical, Computer, and Systems Engineering, Case Western Reserve University, Cleveland, USA.
Ashwin MenonDepartment of Mechanical Engineering, Case Western Reserve University, Cleveland, USA.
Anubhuti BhalotiaDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, USA.
Efstathios KarathanasisDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, USA.
Jeffrey R CapadonaAdvanced Platform Technology Center, Louis Stokes Cleveland Veterans Affairs Medical Center, Cleveland, USA.
Allison Hess-DunningAdvanced Platform Technology Center, Louis Stokes Cleveland Veterans Affairs Medical Center, Cleveland, USA.
Case Western Reserve University · USLouis Stokes Cleveland VA Medical Center · US

Funding

Microelectrodes for Co-Localized Tunable Drug Delivery and Neural RecordingI01RX003950 · VA · LOUIS STOKES CLEVELAND VA MEDICAL CENTER · PI DUNNING, ALLISON HESS · 2022 to 2025
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Advanced Platform Technology Center of ExcellenceI50RX001871 · VA · LOUIS STOKES CLEVELAND VA MEDICAL CENTER · PI MARGOT S. DAMASER, Gilles Pinault · 2015 to 2026
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RRD VA I01 RX003950RRD VA I50 RX001871
6 · The paper itself

Abstract

Abstract: The current work presents a novel flexible multifunctional platform for biological interface applications. The use of titania nanotube arrays (TNAs) as a multifunctional material is explored for soft-tissue interface applications. Impact statement: Titania nanotube arrays (TNAs) are highly tunable and biocompatible structures that lend themselves to multifunctional implementation in implanted devices. A particularly important aspect of titania nanotubes is their ability to serve as nano-reservoirs for drugs or other therapeutic agents that slowly release after implantation. To date, TNAs have been used to promote integration with rigid, dense tissues for dental and orthopedic applications. This work aims to expand the implant applications that can benefit from TNAs by integrating them onto soft polymer substrates, thereby promoting compatibility with soft tissues. The successful direct growth and integration of TNAs on polymer substrates mark a critical step toward developing mechanically compliant implantable systems with drug delivery from nanostructured inorganic functional materials. Diffusion-driven release kinetics and the high drug-loading efficiency of TNAs offer tremendous potential for sustained drug delivery for scientific investigations, to treat injury and disease, and to promote device integration with biological tissues. This work opens new opportunities for developing novel and more effective implanted devices that can significantly improve patient outcomes and quality of life. Graphical abstract: Supplementary information: The online version contains supplementary material available at 10.1557/s43577-023-00628-y.

Indexed as

Electrochemical synthesisFlexible deviceInterfaceLithographyNanostructure

Identifiers

PMID38645611
PMCPMC11026245
OpenAlexW4389476626

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.