Evidence map›Paper›PMID 38645407›Full record

ArticleCase reports in gastroenterology

Fever and Increased Gastrointestinal Uptake on Positron Emission Tomography after Anti-Tumour Necrosis Factor Therapy: A Case Report of Whipple's Disease.

Arteen Arzivian, Brett Jones, Fredrick Joshua, Miriam Paul, Thomas Lynch, Martin Brown, Robin Gasiorowski

Open access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Case reports in gastroenterology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Deciphering whipple's disease complexity.Clinical and experimental medicine · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Arteen ArzivianGastroenterology Department, Macquarie University Hospital, Sydney, NSW, Australia.
Brett JonesGastroenterology Department, Macquarie University Hospital, Sydney, NSW, Australia.
Fredrick JoshuaRheumatology Department, Macquarie University Hospital, Sydney, NSW, Australia.
Miriam PaulDouglass Hanly Moir Pathology, Macquarie Park, Sydney, NSW, Australia.
Thomas LynchDouglass Hanly Moir Pathology, Macquarie Park, Sydney, NSW, Australia.
Martin BrownCardiology Department, Macquarie University Hospital, Sydney, NSW, Australia.
Robin GasiorowskiHaematology Department, Macquarie University Hospital, Sydney, NSW, Australia.
Douglass Hanly Moir Pathology · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Whipple's disease is a rare condition that can present with atypical and non-specific features requiring a high index of suspicion for diagnosis. Case Presentation: We present a case of a man in his 40s with peripheral arthritis and bilateral sacro-ileitis for 4-5 years that was treated with an anti-tumour necrosis factor therapy, which led to worsening of his symptoms, elevation of the inflammatory markers, and the development of fever, night sweats, anorexia, and a significant weight loss. The patient had no abdominal pain, diarrhoea, or other gastrointestinal symptoms. An FDG-PET scan showed increased uptake in the stomach and caecum. Endoscopic examination showed inflammatory changes in the stomach and normal mucosa of the duodenum, jejunum, terminal ileum, caecum, and colon. Histopathology was inconclusive, but the diagnosis was confirmed with Conclusion: This case presents an atypical and challenging presentation of Whipple's disease and the importance of proactive testing for neurological involvement.

Indexed as

Anti-tumour necrosis factorArthritisCase reportTropheryma whippleiWhipple’s disease

Identifiers

PMID38645407
PMCPMC11032180
OpenAlexW4395009508

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.