ArticleBiological psychiatry global open science2024
The Role of Subgenual Resting-State Connectivity Networks in Predicting Prognosis in Major Depressive Disorder.
Article in Biological psychiatry global open science, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Subgenual anterior cingulate cortex in major depression: a systematic review and meta-analysis of MRI studies with patients and healthy controls.Translational psychiatry · 2026Pooled it
- Deep brain stimulation induces white matter remodeling and functional changes to brain-wide networks.Nature neuroscience · 2026Article
- The capacity of brain circuits to enhance psychiatry.Nature medicine · 2024Article
- Neural signatures of emotional biases predict clinical outcomes in difficult-to-treat depression.Research directions. Depression · 2024Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
Background: A seminal study found higher subgenual frontal cortex resting-state connectivity with 2 left ventral frontal regions and the dorsal midbrain to predict better response to psychotherapy versus medication in individuals with treatment-naïve major depressive disorder (MDD). Here, we examined whether these subgenual networks also play a role in the pathophysiology of clinical outcomes in MDD with early treatment resistance in primary care. Methods: Forty-five people with current MDD who had not responded to ≥2 serotonergic antidepressants ( Results: We observed a reversal of our preregistered hypothesis in that higher resting-state connectivity between the subgenual cortex and the a priori ventrolateral prefrontal/insula region predicted favorable rather than unfavorable clinical outcomes ( Conclusions: Subgenual connectivity with the ventrolateral prefrontal cortex/insula is relevant for subsequent clinical outcomes in current MDD with early treatment resistance. Its positive association with favorable outcomes could be explained primarily by psychosocial rather than the expected pharmacological changes during the follow-up period.
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