Evidence map›Paper›PMID 38645265›Full record

ArticlebioRxiv : the preprint server for biology2024

Single Cell Sequencing Provides Clues about the Developmental Genetic Basis of Evolutionary Adaptations in Syngnathid Fishes.

Hope M Healey, Hayden B Penn, Clayton M Small, Susan Bassham, Vithika Goyal, Micah A Woods, William A Cresko

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Hope M HealeyInstitute of Ecology and Evolution, University of Oregon.ORCID 0000-0001-9978-1553
Hayden B PennInstitute of Ecology and Evolution, University of Oregon.ORCID 0009-0000-3090-5423
Clayton M SmallInstitute of Ecology and Evolution, University of Oregon.ORCID 0000-0003-1615-7590
Susan BasshamInstitute of Ecology and Evolution, University of Oregon.ORCID 0000-0002-7309-2095
Vithika GoyalInstitute of Ecology and Evolution, University of Oregon.ORCID 0009-0009-8601-8474
Micah A WoodsInstitute of Ecology and Evolution, University of Oregon.ORCID 0009-0004-2156-3352
William A CreskoInstitute of Ecology and Evolution, University of Oregon.ORCID 0000-0002-3496-8074
University of Oregon · US

Funding

Graduate Training in Genetics Administrative Supplement - Career Curriculum DevelopmentT32GM007413 · NIGMS · UNIVERSITY OF OREGON · PI GUILLEMIN, KAREN J · 1985 to 2022
$7.8M
Discovery of craniofacial genes capable of compensation through evolutionary mutant modelF31DE032559 · NIDCR · UNIVERSITY OF OREGON · PI HEALEY, HOPE M · 2022 to 2024
$77k
NIDCR NIH HHS F31 DE032559NIGMS NIH HHS T32 GM007413
6 · The paper itself

Abstract

Seahorses, pipefishes, and seadragons are fishes from the family Syngnathidae that have evolved extraordinary traits including male pregnancy, elongated snouts, loss of teeth, and dermal bony armor. The developmental genetic and cellular changes that led to the evolution of these traits are largely unknown. Recent syngnathid genome assemblies revealed suggestive gene content differences and provide the opportunity for detailed genetic analyses. We created a single cell RNA sequencing atlas of Gulf pipefish embryos to understand the developmental basis of four traits: derived head shape, toothlessness, dermal armor, and male pregnancy. We completed marker gene analyses, built genetic networks, and examined spatial expression of select genes. We identified osteochondrogenic mesenchymal cells in the elongating face that express regulatory genes

Indexed as

Evolutionary NoveltyEvolution of DevelopmentNon-traditional ModelscRNAseqSyngnathid

Identifiers

PMID38645265
PMCPMC11030337
OpenAlexW4394682582

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.