ArticlemedRxiv : the preprint server for health sciences2024
Functional Analysis of G6PD Variants Associated With Low G6PD Activity in the All of Us Research Program.
Nicholas R Powell, Renee C Geck, Dongbing Lai, Tyler Shugg, Todd C Skaar, Maitreya Dunham
Open access · greenAbstract readPreprint
In one paragraphArticle in medRxiv : the preprint server for health sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
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0citing papers in PubMed
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What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed, 0 citations in OpenAlex.
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4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
6 authors at 2 institutions in 1 country.
Nicholas R PowellIndiana University School of Medicine, Department of Medicine, Division of Clinical Pharmacology, Indianapolis IN.ORCID 0000-0003-4572-0733 Dongbing LaiIndiana University School of Medicine, Department of Medical and Molecular Genetics, Indianapolis IN.
Tyler ShuggIndiana University School of Medicine, Department of Medicine, Division of Clinical Pharmacology, Indianapolis IN.
Todd C SkaarIndiana University School of Medicine, Department of Medicine, Division of Clinical Pharmacology, Indianapolis IN.
Indiana University School of MedicineUniversity of Washington · US
Funding
Translational Bioimaging Core Shared ResourceP30CA015704 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Eric Collisson · 1985 to 2026
$296.4MMIRA-Regulation of drug metabolizing enzymesR35GM131812 · NIGMS · INDIANA UNIVERSITY INDIANAPOLIS · PI SKAAR, TODD C. · 2019 to 2023
$2.5MComprehensive, context-aware, functional analysis of Cytochrome P450 variantsR01GM132162 · NIGMS · UNIVERSITY OF WASHINGTON · PI DUNHAM, MAITREYA J, FOWLER, DOUGLAS M · 2019 to 2022
$2.1MInvestigation of the Immune-Mediated Drug-Drug Interaction Potential of Immune Checkpoint InhibitorsK23GM147805 · NIGMS · INDIANA UNIVERSITY INDIANAPOLIS · PI Tyler A Shugg · 2022 to 2026
$836kFunctional interpretation of human G6PD variants using multiplexed analyses in S. cerevisiaeF32GM143852 · NIGMS · UNIVERSITY OF WASHINGTON · PI GECK, RENEE CATHERINE · 2021 to 2022
$134kNCI NIH HHS P30 CA015704NIGMS NIH HHS F32 GM143852NIGMS NIH HHS K23 GM147805NIGMS NIH HHS R01 GM132162NIGMS NIH HHS R35 GM131812
6 · The paper itselfAbstract
Glucose-6-phosphate dehydrogenase (G6PD) protects red blood cells against oxidative damage through regeneration of NADPH. Individuals with
Indexed as
ACMGAll of UsClinGenClinVarG6PDG6PD deficiencyGlucose-6-phosphate dehydrogenaseGWAShemolytic anemiaLOINCpermutation testingpharmacogeneticsphenotype curationpower simulationvariant interpretationWHO
Identifiers
PMID38645242
PMCPMC11030488
OpenAlexW4394797603
What OpenQuestion holds
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