Evidence map›Paper›PMID 38645225›Full record

ArticlemedRxiv : the preprint server for health sciences2024

Characteristic Fetal Brain MRI Abnormalities in Pyruvate Dehydrogenase Complex Deficiency.

Olivier Fortin, Kelsey Christoffel, Abdullah Shoaib, Charu Venkatesan, Kate Cilli, Jason W Schroeder, Cesar Alves, Rebecca D Ganetzky, Jamie L Fraser

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 2 countries.

Olivier FortinZickler Family Prenatal Pediatrics Institute, Children's National Hospital, Washington, District of Columbia, USA, 20010.
Kelsey ChristoffelZickler Family Prenatal Pediatrics Institute, Children's National Hospital, Washington, District of Columbia, USA, 20010.
Abdullah ShoaibDepartment of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas, USA, 75235.
Charu VenkatesanDivision of Neurology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA, 45229.
Kate CilliZickler Family Prenatal Pediatrics Institute, Children's National Hospital, Washington, District of Columbia, USA, 20010.
Jason W SchroederDepartment of Radiology, Children's National Hospital, Washington, District of Columbia, USA, 20010.
Cesar AlvesDepartment of Radiology, Boston Children's Hospital, Boston, Massachusetts, USA, 02115.
Rebecca D GanetzkyDivision of Human Genetics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA, 19104.
Jamie L FraserZickler Family Prenatal Pediatrics Institute, Children's National Hospital, Washington, District of Columbia, USA, 20010.ORCID 0000-0002-7794-8903
Children's National · USBoston Children's Hospital · USChildren's Hospital of Philadelphia · USCincinnati Children's Hospital Medical Center · USSouthwestern Medical Center

Funding

Validation of the GMFC-MLDU54NS115052 · NINDS · CHILDREN'S HOSP OF PHILADELPHIA · PI Laura Ann Adang · 2019 to 2026
$14.3M
Clinical Outcomes in Aicardi Goutières SyndromeU01NS106845 · NINDS · CHILDREN'S HOSP OF PHILADELPHIA · PI VANDERVER, ADELINE LUCIE · 2019 to 2023
$7.5M
Diversity Supplement: Clinical Pediatric Research Training for the Fetal-Neonatal BrainT32HD098066 · NICHD · CHILDREN'S RESEARCH INSTITUTE · PI DU PLESSIS, ADRE JACQUES, LIMPEROPOULOS, CATHERINE · 2020 to 2024
$1.7M
GLIA-CTN Genomic Expert Curation PanelU24NS131172 · NINDS · CHILDREN'S HOSP OF PHILADELPHIA · PI VANDERVER, ADELINE LUCIE · 2023 to 2025
$1.1M
NICHD NIH HHS T32 HD098066NINDS NIH HHS U01 NS106845NINDS NIH HHS U24 NS131172NINDS NIH HHS U54 NS115052
6 · The paper itself

Abstract

Pyruvate dehydrogenase complex deficiency (PDCD) is a disorder of mitochondrial metabolism that is caused by pathogenic variants in multiple genes, including

Indexed as

Fetal imagingFetal neurogeneticsMetabolic disordersMitochondrial disordersPrenatal genetic testing

Identifiers

PMID38645225
PMCPMC11030481
OpenAlexW4394674715

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.