Evidence map›Paper›PMID 38645210›Full record

ArticlebioRxiv : the preprint server for biology2024

Spinal microcircuits go through multiphasic homeostatic compensations in a mouse model of motoneuron degeneration.

Filipe Nascimento, M Görkem Özyurt, Kareen Halablab, Gardave Singh Bhumbra, Guillaume Caron, Marcin Bączyk, Daniel Zytnicki, Marin Manuel, Francesco Roselli, Rob Brownstone and 1 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 6 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 4 countries.

Filipe NascimentoDepartment of Neuroscience Physiology and Pharmacology (NPP), Gower Street, University College London, WC1E 6BT, UK.ORCID 0000-0002-9426-2807
M Görkem ÖzyurtDepartment of Neuroscience Physiology and Pharmacology (NPP), Gower Street, University College London, WC1E 6BT, UK.ORCID 0000-0003-2531-1174
Kareen HalablabDepartment of Neurology, Ulm University, Ulm, Germany.
Gardave Singh BhumbraDepartment of Neuroscience Physiology and Pharmacology (NPP), Gower Street, University College London, WC1E 6BT, UK.
Guillaume CaronSaints-Pères Paris Institute for the Neurosciences (SPPIN), Université Paris Cité, Centre National de la Recherche Scientifique (CNRS), Paris, France.
Marcin BączykDepartment of Neurobiology, Poznań University of Physical Education, Poznań, Poland.
Daniel ZytnickiSaints-Pères Paris Institute for the Neurosciences (SPPIN), Université Paris Cité, Centre National de la Recherche Scientifique (CNRS), Paris, France.
Marin ManuelDepartment of Biomedical and Pharmaceutical Sciences, College of Pharmacy, University of Rhode Island, USA.
Francesco RoselliDepartment of Neurology, Ulm University, Ulm, Germany.
Rob BrownstoneDepartment of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, University College London, London WC1N 3BG, UK.
Marco BeatoDepartment of Neuroscience Physiology and Pharmacology (NPP), Gower Street, University College London, WC1E 6BT, UK.
National Hospital for Neurology and Neurosurgery · GBCentre National de la Recherche Scientifique · FRUniversität Ulm · DEUniversity College London · GBUniversity of Rhode Island · US

Funding

Motoneuron mortality in neurodegenerative diseases induced by homeostatic dysregulation of excitabilityR01NS110953 · NINDS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI BINDER, MARC D, HECKMAN, CHARLES · 2019 to 2023
$2.8M
NINDS NIH HHS R01 NS110953Wellcome Trust
6 · The paper itself

Abstract

In many neurological conditions, early-stage neural circuit adaption can preserve relatively normal behaviour. In some diseases, spinal motoneurons progressively degenerate yet movement is initially preserved. We therefore investigated whether these neurons and associated microcircuits adapt in a mouse model of progressive motoneuron degeneration. Using a combination of

Indexed as

electrophysiologyglycine receptorsmotoneuronsmotor controlquantal analysisRenshaw cellssensory afferentsspinal cord

Identifiers

PMID38645210
PMCPMC11030447
OpenAlexW4394795750

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.