Evidence map›Paper›PMID 38645209›Full record

ArticlebioRxiv : the preprint server for biology2024

Comparative modeling reveals the molecular determinants of aneuploidy fitness cost in a wild yeast model.

Julie Rojas, James Hose, H Auguste Dutcher, Michael Place, John F Wolters, Chris Todd Hittinger, Audrey P Gasch

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Julie RojasCenter for Genomic Science Innovation, University of Wisconsin-Madison, Madison, WI 53706, USA.ORCID 0000-0001-8714-1532
James HoseCenter for Genomic Science Innovation, University of Wisconsin-Madison, Madison, WI 53706, USA.
H Auguste DutcherCenter for Genomic Science Innovation, University of Wisconsin-Madison, Madison, WI 53706, USA.ORCID 0000-0003-2013-4391
Michael PlaceCenter for Genomic Science Innovation, University of Wisconsin-Madison, Madison, WI 53706, USA.ORCID 0000-0003-2776-7095
John F WoltersLaboratory of Genetics, University of Wisconsin-Madison, Madison, WI 53706, USA.ORCID 0000-0002-5477-4250
Chris Todd HittingerCenter for Genomic Science Innovation, University of Wisconsin-Madison, Madison, WI 53706, USA.ORCID 0000-0001-5088-7461
Audrey P GaschCenter for Genomic Science Innovation, University of Wisconsin-Madison, Madison, WI 53706, USA.ORCID 0000-0002-8182-257X

Funding

Institutional Training in the Genomic SciencesT32HG002760 · NHGRI · UNIVERSITY OF WISCONSIN-MADISON · PI Qiongshi Lu · 2003 to 2026
$17.7M
PREDOCTORAL TRAINING PROGRAM IN GENETICST32GM007133 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI PERNA, NICOLE T · 1985 to 2023
$16.5M
Molecular approaches to sensitizing eukaryotic cells to aneuploidyR01CA229532 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI GASCH, AUDREY · 2018 to 2022
$1.8M
Dissecting the influence of genetic background on aneuploidy tolerance in the model eukaryote Saccharomyces cerevisiaeR01GM147271 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI GASCH, AUDREY · 2022 to 2025
$1.2M
NCI NIH HHS R01 CA229532NHGRI NIH HHS T32 HG002760NIGMS NIH HHS R01 GM147271NIGMS NIH HHS T32 GM007133
6 · The paper itself

Abstract

Although implicated as deleterious in many organisms, aneuploidy can underlie rapid phenotypic evolution. However, aneuploidy will only be maintained if the benefit outweighs the cost, which remains incompletely understood. To quantify this cost and the molecular determinants behind it, we generated a panel of chromosome duplications in

Indexed as

AneuploidyBalance hypothesisCNVdosage-sensitive genessnoRNAtRNA

Identifiers

PMID38645209
PMCPMC11030387

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.