Evidence map›Paper›PMID 38645200›Full record

ArticlebioRxiv : the preprint server for biology2024

Divergence of Grainy head affects chromatin accessibility, gene expression, and embryonic viability in

Henry A Ertl, Erick X Bayala, Mohammad A Siddiq, Patricia J Wittkopp

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Henry A ErtlDepartment of Ecology and Evolutionary Biology, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0000-0003-0028-304X
Erick X BayalaDepartment of Ecology and Evolutionary Biology, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0000-0002-9736-2002
Mohammad A SiddiqDepartment of Ecology and Evolutionary Biology, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0000-0002-9186-1978
Patricia J WittkoppDepartment of Ecology and Evolutionary Biology, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0000-0001-7619-0048
University of Michigan · US

Funding

Genetic mechanisms and evolutionary processes underlying diversity within and between speciesR35GM118073 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI WITTKOPP, PATRICIA JEAN · 2016 to 2025
$4.1M
Genetic mechanisms and coevolutionary interactions in the evolution of gene expression divergenceF32CA261115 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SIDDIQ, MOHAMMAD · 2021 to 2023
$210k
NCI NIH HHS F32 CA261115NIGMS NIH HHS R35 GM118073
6 · The paper itself

Abstract

Pioneer factors are critical for gene regulation and development because they bind chromatin and make DNA more accessible for binding by other transcription factors. The pioneer factor Grainy head (Grh) is present across metazoans and has been shown to retain a role in epithelium development in fruit flies, nematodes, and mice despite extensive divergence in both amino acid sequence and length. Here, we investigate the evolution of Grh function by comparing the effects of the fly (

Indexed as

Caenorhabditis elegansembryoevolutionpioneer factortranscription factor

Identifiers

PMID38645200
PMCPMC11030446
OpenAlexW4394673766

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.