Evidence map›Paper›PMID 38645182›Full record

ArticlebioRxiv : the preprint server for biology2024

STING promotes homeostatic maintenance of tissues and confers longevity with aging.

Jacob W Hopkins, Katherine B Sulka, Machlan Sawden, Kimberly A Carroll, Ronald D Brown, Stephen C Bunnell, Alexander Poltorak, Albert Tai, Eric R Reed, Shruti Sharma

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Jacob W HopkinsDepartment of Immunology, Tufts University, Boston, MA 02111.
Katherine B SulkaDepartment of Immunology, Tufts University, Boston, MA 02111.
Machlan SawdenDepartment of Immunology, Tufts University, Boston, MA 02111.
Kimberly A CarrollDepartment of Immunology, Tufts University, Boston, MA 02111.
Ronald D BrownDepartment of Neurobiology and Behavior, Cornell University, Ithaca, NY, 12853.
Stephen C BunnellDepartment of Immunology, Tufts University, Boston, MA 02111.ORCID 0000-0001-6887-0828
Alexander PoltorakDepartment of Immunology, Tufts University, Boston, MA 02111.
Albert TaiDepartment of Immunology, Tufts University, Boston, MA 02111.
Eric R ReedData Intensive Studies Center, Tufts University, Medford, MA, 02155.ORCID 0000-0003-2347-720X
Shruti SharmaDepartment of Immunology, Tufts University, Boston, MA 02111.
Tufts University · US

Funding

Regulation of LPS-responses by ZBP1R01AI167245 · NIAID · TUFTS UNIVERSITY BOSTON · PI POLTORAK, ALEXANDER · 2021 to 2025
$3.6M
Intracellular nucleic acid sensing and age-related chronic inflammationR01AI142005 · NIAID · TUFTS UNIVERSITY BOSTON · PI SHARMA, SHRUTI · 2019 to 2023
$2.3M
Cytosolic DNA sensing instructs resident macrophage vitality and organismal longevityR56AG082812 · NIA · TUFTS UNIVERSITY BOSTON · PI SHARMA, SHRUTI · 2023 to 2023
$409k
NIAID NIH HHS R01 AI142005NIAID NIH HHS R01 AI167245NIA NIH HHS R56 AG082812
6 · The paper itself

Abstract

Local immune processes within aging tissues are a significant driver of aging associated dysfunction, but tissue-autonomous pathways and cell types that modulate these responses remain poorly characterized. The cytosolic DNA sensing pathway, acting through cyclic GMP-AMP synthase (cGAS) and Stimulator of Interferon Genes (STING), is broadly expressed in tissues, and is poised to regulate local type I interferon (IFN-I)-dependent and independent inflammatory processes within tissues. Recent studies suggest that the cGAS/STING pathway may drive pathology in various

Identifiers

PMID38645182
PMCPMC11030237
OpenAlexW4394616088

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.