Evidence map›Paper›PMID 38645173›Full record

ArticlebioRxiv : the preprint server for biology2024

β-arrestin-biased Allosteric Modulator of Neurotensin Receptor 1 Reduces Ethanol Drinking and Responses to Ethanol Administration in Rodents.

Graydon B Gereau, Diana Zhou, Kalynn Van Voorhies, Ryan E Tyler, Jeffrey Campbell, Jackson G Murray, Ali Alvarez-Pamir, Luke A Wykoff, Michel A Companion, Michael R Jackson and 6 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 5 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors at 4 institutions in 1 country.

Graydon B GereauBowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, USA.ORCID 0000-0003-2928-5743
Diana ZhouBowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, USA.
Kalynn Van VoorhiesBowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, USA.
Ryan E TylerBowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, USA.
Jeffrey CampbellBowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, USA.
Jackson G MurrayBowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, USA.
Ali Alvarez-PamirBowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, USA.
Luke A WykoffBowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, USA.
Michel A CompanionBowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, USA.
Michael R JacksonSanford Burnham Prebys, La Jolla, USA.
Steven H OlsonSanford Burnham Prebys, La Jolla, USA.
Lawrence S BarakDepartment of Cell Biology, Duke University, Durham, USA.
Lauren M SloskyDepartment of Pharmacology, University of Minnesota Medical School, Minneapolis, USA.
Ryan P VetrenoBowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, USA.
Joyce BesheerBowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, USA.
Zoe A McElligottBowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, USA.ORCID 0000-0002-4717-5698
University of North Carolina at Chapel Hill · USSanford Burnham Prebys Medical Discovery Institute · USDuke University · USUniversity of Minnesota System · US

Funding

UNIV OF NORTH CAROLINA CLINICAL NUTRITION RESEARCH UNITP30DK056350 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Ian Michael Carroll · 1999 to 2026
$31.6M
Supplement to Molecular and Cellular Studies on Alcohol's ActionsT32AA007573 · NIAAA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI FULTON T CREWS, Thomas L. Kash · 1997 to 2026
$9.3M
Development of SBI-553, an allosteric modulator of NTR1, for the treatment of substance use disordersUH3DA050316 · NIDA · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI BARAK, LAWRENCE S., JACKSON, MICHAEL · 2023 to 2024
$6.4M
Characterization of alcohol self-administration following predator odor exposure: relevance to PTSD-Diversity SupplementR01AA026537 · NIAAA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Joyce Besheer · 2017 to 2026
$3.9M
Development of SBI-553, an allosteric modulator of NTR1, for the treatment of substance use disordersUG3DA050316 · NIDA · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI BARAK, LAWRENCE S., CARON, MARC G. · 2019 to 2019
$3.6M
Neurotensin receptor 1 as a novel target for opioid use disorder and discovery of new small molecule probesR01DA061773 · NIDA · UNIVERSITY OF MINNESOTA · PI Steven H Olson, Lauren M Slosky · 2024 to 2026
$2.1M
Probing central amygdala neurotensin neurons in alcohol consumptionR01AA026363 · NIAAA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MCELLIGOTT, ZOE ANASTASIA · 2020 to 2024
$2.0M
Leveraging Functional Selectivity in the Neurotensin Receptor 1-Mediated Treatment of AddictionR00DA048970 · NIDA · UNIVERSITY OF MINNESOTA · PI SLOSKY, LAUREN M · 2022 to 2024
$747k
A novel platform for quantification of acute neuronal transcriptional responsesR43DA057749 · NIDA · EPICYPHER, INC. · PI SUN, ZU-WEN · 2022 to 2022
$327k
NIAAA NIH HHS R01 AA026363NIAAA NIH HHS R01 AA026537NIAAA NIH HHS T32 AA007573NIDA NIH HHS R00 DA048970NIDA NIH HHS R01 DA061773NIDA NIH HHS R43 DA057749NIDA NIH HHS UG3 DA050316NIDA NIH HHS UH3 DA050316NIDDK NIH HHS P30 DK056350
6 · The paper itself

Abstract

Alcohol use disorders (AUDs) impose an enormous societal and financial burden, and world-wide, alcohol misuse is the 7

Identifiers

PMID38645173
PMCPMC11030371
OpenAlexW4394790330

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.