Evidence map›Paper›PMID 38645093›Full record

ArticlebioRxiv : the preprint server for biology2024

The DNA Methyltransferase DMAP1 is Required for Tissue Maintenance and Planarian Regeneration.

Salvador Rojas, Paul G Barghouth, Peter Karabinis, Néstor J Oviedo

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Salvador RojasDepartment of Molecular & Cell Biology, University of California, Merced, CA, 95343.
Paul G BarghouthDepartment of Molecular & Cell Biology, University of California, Merced, CA, 95343.
Peter KarabinisDepartment of Molecular & Cell Biology, University of California, Merced, CA, 95343.
Néstor J OviedoDepartment of Molecular & Cell Biology, University of California, Merced, CA, 95343.ORCID 0000-0002-0213-9781
University of California, Merced · US

Funding

The Effects of Direct Current Stimulation in Adult TissuesR01GM132753 · NIGMS · UNIVERSITY OF CALIFORNIA, MERCED · PI OVIEDO, NESTOR J · 2019 to 2022
$1.2M
NIGMS NIH HHS R01 GM132753
6 · The paper itself

Abstract

The precise regulation of transcription is required for embryonic development, adult tissue turnover, and regeneration. Epigenetic modifications play a crucial role in orchestrating and regulating the transcription of genes. These modifications are important in the transition of pluripotent stem cells and their progeny. Methylation, a key epigenetic modification, influences gene expression through changes in histone tails and direct DNA methylation. Work in different organisms has shown that the DNA methyltransferase-1-associated protein (DMAP1) may associate with other molecules to repress transcription through DNA methylation. Thus, DMAP1 is a versatile protein implicated in a myriad of events, including pluripotency maintenance, DNA damage repair, and tumor suppression. While DMAP1 has been extensively studied

Indexed as

axial polarityepigeneticsneoblastsPlanariaregenerationtissue maintenance

Identifiers

PMID38645093
PMCPMC11030423
OpenAlexW4394719486

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.